Increased xanthine oxidase activity after traumatic brain injury in rats

Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxidation after TBI. In this study, we investigate the time-dependent ch...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2005-04, Vol.12 (3), p.273-275
Main Authors: Solaroglu, Ihsan, Okutan, Ozerk, Kaptanoglu, Erkan, Beskonakli, Etem, Kilinc, Kamer
Format: Article
Language:English
Subjects:
Animals
Brain - enzymology
Brain Injuries - enzymology
Brain Injuries - pathology
brain injury
Cytoplasm - enzymology
Free Radicals - metabolism
lipid peroxidation
Lipid Peroxidation - drug effects
Male
Nitric Oxide Synthase - metabolism
oxygen free radical
Rats
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances - metabolism
xanthine oxidase
Xanthine Oxidase - metabolism
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Summary:Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxidation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxidation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxidation by-products and in XO enzyme activity after TBI.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2004.12.002