Usefulness of sublingual isosorbide to assess the reversibility of pulmonary hypertension in cardiac transplant candidates

Continuous infusion of short life vasodilators are employed to test reversibility of pulmonary hypertension in cardiac transplant candidates. Sublingual isosorbide administration has not been described in the literature and it might be a simpler alternative. To evaluate sublingual isosorbide adminis...

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Bibliographic Details
Published in:Revista medíca de Chile 2006-02, Vol.134 (2), p.201-206
Main Authors: Baraona, Fernando, Castro, Pablo, Pérez, Osvaldo, Morán, Sergio, Zalaquett, Ricardo, Irarrázabal, Manuel J, Jalil, Jorge
Format: Article
Language:Spanish
Subjects:
Administration, Sublingual
Cardiac Catheterization
Cardiac Output, Low - etiology
Cardiac Output, Low - surgery
Diuretics, Osmotic - administration & dosage
Female
Heart Transplantation
Humans
Hypertension, Pulmonary - drug therapy
Isosorbide - administration & dosage
Male
Middle Aged
Prospective Studies
Vasodilator Agents - administration & dosage
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Summary:Continuous infusion of short life vasodilators are employed to test reversibility of pulmonary hypertension in cardiac transplant candidates. Sublingual isosorbide administration has not been described in the literature and it might be a simpler alternative. To evaluate sublingual isosorbide administration as a test of reversibility of pulmonary hypertension in heart failure. Prospective evaluation of patients referred for cardiac transplant evaluation. Patients underwent right catheterization for hemodynamic measurements at baseline and after repeated doses of 5 mg sublingual isosorbide every 5 minutes until observing a decrease in pulmonary vascular resistance decrease or symptomatic hypotension. Twenty one patients, 18 men, age 49+/-15 years, were studied. Fourteen (66%) were transplanted. The mean sublingual isosorbide dose was 15+/-5 mg. After isosorbide administration, there was a significant decrease in mean arterial pressure (80+/-8.5 to 71+/-6.6 mmHg, p
ISSN:0034-9887