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The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival
: Background: Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrh...
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| Published in: | Clinical transplantation 2006-01, Vol.20 (1), p.91-95 |
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| container_start_page | 91 |
| container_title | Clinical transplantation |
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| creator | Johnston, Olwyn O'Kelly, Patrick Spencer, Susan Cunningham, Phyllis Dorman, Anthony Donohoe, John Walshe, Joseph J Hickey, David Little, Dilly M Conlon, Peter J |
| description | : Background: Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrhage (SIH) compared with those with other causes of death (OCOD).
Methods: Between 1990 and 2001, 1526 renal transplants were performed (711 SIH donors and 815 OCOD donors) at our unit. Serum creatinine levels at 1 yr, graft half‐life and annual graft failure rate were measured for both groups. Renal graft and patient survivals between the groups were compared. Relative risk for SIH donors and other confounding variables was measured using Cox proportional hazards models.
Results: Graft half‐life results were obtained for SIH (8 yr) and OCOD (10.13 yr) recipients. Graft and patient survival at 5 and 10 yr was 68.5% and 39.3% respectively for the SIH group vs. 76.8% and 51.9% respectively for the OCOD group (p |
| doi_str_mv | 10.1111/j.1399-0012.2005.00446.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67782688</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67782688</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4346-8ad365b2e7f5c85a83d5ae1c8d5ff9e2eda83019b5484fa05d9b1ed26286fe303</originalsourceid><addsrcrecordid>eNqNkM2O0zAURi0EYsrAKyBvYJeMncSOI7FBEbRII5BQAYmN5SbXrUtiB9vtdN4ed1LNbPHCvro-n38OQpiSnKZxs89p2TQZIbTIC0JYTkhV8fz0DC0eN56jBWlIkWpeXqFXIexTl1POXqKrNLNU0gW6W-8Am3FSXcRO495Z53GYnI3KgjsEbGz0qvPKGjXgnYLReb9TW8DHkGMXd-DnUMDO4sHZbRbBj9iDTfzWKx2xsj2eVDRgIw4HfzRHNbxGL7QaAry5rNfox-dP63aV3X5bfmk_3mZdVVY8E6ovOdsUUGvWCaZE2TMFtBM907qBAvrUIrTZsEpUWhHWNxsKfcELwTWUpLxG7-dzJ-_-HiBEOZrQwTDM35O8rkXBhUigmMHOuxA8aDl5Myp_LymRZ-lyL89u5dmtPEuXD9LlKUXfXu44bEbon4IXywl4dwFU6NSgk83OhCeuZjWhlCXuw8zdmQHu__sBsl1_T0WKZ3PchAinx7jyf9I3y5rJX1-Xsm1WP9vl6rck5T-YkK5X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67782688</pqid></control><display><type>article</type><title>The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Johnston, Olwyn ; O'Kelly, Patrick ; Spencer, Susan ; Cunningham, Phyllis ; Dorman, Anthony ; Donohoe, John ; Walshe, Joseph J ; Hickey, David ; Little, Dilly M ; Conlon, Peter J</creator><creatorcontrib>Johnston, Olwyn ; O'Kelly, Patrick ; Spencer, Susan ; Cunningham, Phyllis ; Dorman, Anthony ; Donohoe, John ; Walshe, Joseph J ; Hickey, David ; Little, Dilly M ; Conlon, Peter J</creatorcontrib><description>: Background: Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrhage (SIH) compared with those with other causes of death (OCOD).
Methods: Between 1990 and 2001, 1526 renal transplants were performed (711 SIH donors and 815 OCOD donors) at our unit. Serum creatinine levels at 1 yr, graft half‐life and annual graft failure rate were measured for both groups. Renal graft and patient survivals between the groups were compared. Relative risk for SIH donors and other confounding variables was measured using Cox proportional hazards models.
Results: Graft half‐life results were obtained for SIH (8 yr) and OCOD (10.13 yr) recipients. Graft and patient survival at 5 and 10 yr was 68.5% and 39.3% respectively for the SIH group vs. 76.8% and 51.9% respectively for the OCOD group (p < 0.001). However, SIH graft recipients were significantly older with more females. After adjustment for differences in baseline variables between the groups, donor cause of death did not have an independent effect on long‐term graft or patient survival.
Conclusion: Spontaneous intracranial haemorrhage as a cause of donor death, failed to have a significant independent effect on long‐term allograft and patient survival.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/j.1399-0012.2005.00446.x</identifier><identifier>PMID: 16556161</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; cadaveric donor ; Cause of Death ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Survival ; Humans ; Intracranial Hemorrhages ; kidney transplantation ; Kidney Transplantation - immunology ; Kidney Transplantation - mortality ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; patient survival ; Proportional Hazards Models ; Retrospective Studies ; spontaneous intracranial haemorrhage ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Survival Analysis ; Tissue Donors ; Tissue, organ and graft immunology ; Transplantation, Homologous ; Treatment Outcome</subject><ispartof>Clinical transplantation, 2006-01, Vol.20 (1), p.91-95</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4346-8ad365b2e7f5c85a83d5ae1c8d5ff9e2eda83019b5484fa05d9b1ed26286fe303</citedby><cites>FETCH-LOGICAL-c4346-8ad365b2e7f5c85a83d5ae1c8d5ff9e2eda83019b5484fa05d9b1ed26286fe303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17570115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16556161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnston, Olwyn</creatorcontrib><creatorcontrib>O'Kelly, Patrick</creatorcontrib><creatorcontrib>Spencer, Susan</creatorcontrib><creatorcontrib>Cunningham, Phyllis</creatorcontrib><creatorcontrib>Dorman, Anthony</creatorcontrib><creatorcontrib>Donohoe, John</creatorcontrib><creatorcontrib>Walshe, Joseph J</creatorcontrib><creatorcontrib>Hickey, David</creatorcontrib><creatorcontrib>Little, Dilly M</creatorcontrib><creatorcontrib>Conlon, Peter J</creatorcontrib><title>The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>: Background: Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrhage (SIH) compared with those with other causes of death (OCOD).
Methods: Between 1990 and 2001, 1526 renal transplants were performed (711 SIH donors and 815 OCOD donors) at our unit. Serum creatinine levels at 1 yr, graft half‐life and annual graft failure rate were measured for both groups. Renal graft and patient survivals between the groups were compared. Relative risk for SIH donors and other confounding variables was measured using Cox proportional hazards models.
Results: Graft half‐life results were obtained for SIH (8 yr) and OCOD (10.13 yr) recipients. Graft and patient survival at 5 and 10 yr was 68.5% and 39.3% respectively for the SIH group vs. 76.8% and 51.9% respectively for the OCOD group (p < 0.001). However, SIH graft recipients were significantly older with more females. After adjustment for differences in baseline variables between the groups, donor cause of death did not have an independent effect on long‐term graft or patient survival.
Conclusion: Spontaneous intracranial haemorrhage as a cause of donor death, failed to have a significant independent effect on long‐term allograft and patient survival.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>cadaveric donor</subject><subject>Cause of Death</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Intracranial Hemorrhages</subject><subject>kidney transplantation</subject><subject>Kidney Transplantation - immunology</subject><subject>Kidney Transplantation - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>patient survival</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>spontaneous intracranial haemorrhage</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Survival Analysis</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkM2O0zAURi0EYsrAKyBvYJeMncSOI7FBEbRII5BQAYmN5SbXrUtiB9vtdN4ed1LNbPHCvro-n38OQpiSnKZxs89p2TQZIbTIC0JYTkhV8fz0DC0eN56jBWlIkWpeXqFXIexTl1POXqKrNLNU0gW6W-8Am3FSXcRO495Z53GYnI3KgjsEbGz0qvPKGjXgnYLReb9TW8DHkGMXd-DnUMDO4sHZbRbBj9iDTfzWKx2xsj2eVDRgIw4HfzRHNbxGL7QaAry5rNfox-dP63aV3X5bfmk_3mZdVVY8E6ovOdsUUGvWCaZE2TMFtBM907qBAvrUIrTZsEpUWhHWNxsKfcELwTWUpLxG7-dzJ-_-HiBEOZrQwTDM35O8rkXBhUigmMHOuxA8aDl5Myp_LymRZ-lyL89u5dmtPEuXD9LlKUXfXu44bEbon4IXywl4dwFU6NSgk83OhCeuZjWhlCXuw8zdmQHu__sBsl1_T0WKZ3PchAinx7jyf9I3y5rJX1-Xsm1WP9vl6rck5T-YkK5X</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Johnston, Olwyn</creator><creator>O'Kelly, Patrick</creator><creator>Spencer, Susan</creator><creator>Cunningham, Phyllis</creator><creator>Dorman, Anthony</creator><creator>Donohoe, John</creator><creator>Walshe, Joseph J</creator><creator>Hickey, David</creator><creator>Little, Dilly M</creator><creator>Conlon, Peter J</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival</title><author>Johnston, Olwyn ; O'Kelly, Patrick ; Spencer, Susan ; Cunningham, Phyllis ; Dorman, Anthony ; Donohoe, John ; Walshe, Joseph J ; Hickey, David ; Little, Dilly M ; Conlon, Peter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4346-8ad365b2e7f5c85a83d5ae1c8d5ff9e2eda83019b5484fa05d9b1ed26286fe303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>cadaveric donor</topic><topic>Cause of Death</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Intracranial Hemorrhages</topic><topic>kidney transplantation</topic><topic>Kidney Transplantation - immunology</topic><topic>Kidney Transplantation - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>patient survival</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>spontaneous intracranial haemorrhage</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Survival Analysis</topic><topic>Tissue Donors</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnston, Olwyn</creatorcontrib><creatorcontrib>O'Kelly, Patrick</creatorcontrib><creatorcontrib>Spencer, Susan</creatorcontrib><creatorcontrib>Cunningham, Phyllis</creatorcontrib><creatorcontrib>Dorman, Anthony</creatorcontrib><creatorcontrib>Donohoe, John</creatorcontrib><creatorcontrib>Walshe, Joseph J</creatorcontrib><creatorcontrib>Hickey, David</creatorcontrib><creatorcontrib>Little, Dilly M</creatorcontrib><creatorcontrib>Conlon, Peter J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnston, Olwyn</au><au>O'Kelly, Patrick</au><au>Spencer, Susan</au><au>Cunningham, Phyllis</au><au>Dorman, Anthony</au><au>Donohoe, John</au><au>Walshe, Joseph J</au><au>Hickey, David</au><au>Little, Dilly M</au><au>Conlon, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2006-01</date><risdate>2006</risdate><volume>20</volume><issue>1</issue><spage>91</spage><epage>95</epage><pages>91-95</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>: Background: Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrhage (SIH) compared with those with other causes of death (OCOD).
Methods: Between 1990 and 2001, 1526 renal transplants were performed (711 SIH donors and 815 OCOD donors) at our unit. Serum creatinine levels at 1 yr, graft half‐life and annual graft failure rate were measured for both groups. Renal graft and patient survivals between the groups were compared. Relative risk for SIH donors and other confounding variables was measured using Cox proportional hazards models.
Results: Graft half‐life results were obtained for SIH (8 yr) and OCOD (10.13 yr) recipients. Graft and patient survival at 5 and 10 yr was 68.5% and 39.3% respectively for the SIH group vs. 76.8% and 51.9% respectively for the OCOD group (p < 0.001). However, SIH graft recipients were significantly older with more females. After adjustment for differences in baseline variables between the groups, donor cause of death did not have an independent effect on long‐term graft or patient survival.
Conclusion: Spontaneous intracranial haemorrhage as a cause of donor death, failed to have a significant independent effect on long‐term allograft and patient survival.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16556161</pmid><doi>10.1111/j.1399-0012.2005.00446.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical transplantation, 2006-01, Vol.20 (1), p.91-95 |
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| subjects | Adult Biological and medical sciences cadaveric donor Cause of Death Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival Humans Intracranial Hemorrhages kidney transplantation Kidney Transplantation - immunology Kidney Transplantation - mortality Male Medical sciences Middle Aged Multivariate Analysis patient survival Proportional Hazards Models Retrospective Studies spontaneous intracranial haemorrhage Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Survival Analysis Tissue Donors Tissue, organ and graft immunology Transplantation, Homologous Treatment Outcome |
| title | The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival |
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