The use of biochemical markers in prenatal diagnosis of intrauterine growth retardation: insulin-like growth factor I, Leptin, and alpha-fetoprotein

To determine the relation between weight deficit at birth and IGF-I, IGFBP-I, Leptin, and AFP levels in amniotic fluid after 14–18 weeks; to assess the diagnostic usefulness of these biochemical markers. Longitudinal, prospective study. Amniocentesis was performed in pregnant women after 14–18 weeks...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2005-05, Vol.120 (1), p.27-32
Main Authors: Roig, M. Dolores Gómez, Sabrià, Joan, Valls, Carme, Borràs, Miquel, Miró, Elisabet, Ponce, Jordi, Vicens, José M. Laïlla
Format: Article
Language:English
Subjects:
Alpha-fetoprotein
alpha-Fetoproteins - analysis
Amniocentesis
Amniotic Fluid - chemistry
Biological and medical sciences
Biomarkers - analysis
Diseases of mother, fetus and pregnancy
Fetal Growth Retardation - diagnosis
Gestational Age
Gynecology. Andrology. Obstetrics
Insulin-Like Growth Factor Binding Protein 1 - analysis
Insulin-like growth factor binding protein I
Insulin-like growth factor I
Insulin-Like Growth Factor I - analysis
Intrauterine growth retardation
Leptin
Leptin - analysis
Longitudinal Studies
Medical sciences
Pregnancy. Fetus. Placenta
Prospective Studies
Sensitivity and Specificity
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Summary:To determine the relation between weight deficit at birth and IGF-I, IGFBP-I, Leptin, and AFP levels in amniotic fluid after 14–18 weeks; to assess the diagnostic usefulness of these biochemical markers. Longitudinal, prospective study. Amniocentesis was performed in pregnant women after 14–18 weeks of gestation. Study population: 86 controls, 18 IUGR
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2004.07.028