Biosensors for real-time in vivo measurements

The current status of sensors capable of continuous measurement of analytes in biological media is reviewed. This review containing 173 references deals with devices whose use in single cells, tissue slices, animal models and humans has been demonstrated. In addition to sensors specific for glucose,...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2005-06, Vol.20 (12), p.2388-2403
Main Authors: Wilson, George S., Gifford, Raeann
Format: Article
Language:English
Subjects:
Biocompatibility
Biological and medical sciences
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Biosensing Techniques - trends
Biosensor
Biosensors
Biotechnology
Blood Glucose - analysis
Blood Glucose Self-Monitoring - instrumentation
Blood Glucose Self-Monitoring - methods
Cell Culture Techniques - instrumentation
Cell Culture Techniques - methods
Continuous monitoring of glucose
Equipment Design
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Monitoring, Ambulatory - instrumentation
Monitoring, Ambulatory - methods
Prostheses and Implants
Transducers
Various methods and equipments
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Summary:The current status of sensors capable of continuous measurement of analytes in biological media is reviewed. This review containing 173 references deals with devices whose use in single cells, tissue slices, animal models and humans has been demonstrated. In addition to sensors specific for glucose, lactate, glutamate, pyruvate, choline and acetylcholine, insights obtained from monitoring nitric oxide, Na +, K +, Ca 2+, and dopamine are presented. Performance criteria for sensor performance are described as is the subject of biosensor calibration. Biocompatibility issues are dealt with in some detail as is the status of continuous blood glucose monitoring in humans.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2004.12.003