Direct one-pot conversion of acylated carbohydrates into their alkylated derivatives under heterogeneous reaction conditions using solid NaOH and a phase transfer catalyst

[Display omitted] A convenient one-pot protocol for the direct conversion of acyl-protected carbohydrates into their alkylated counterparts has been developed by using alkyl halides in the presence of solid sodium hydroxide and a phase transfer catalyst. These economically convenient, mild, two-phas...

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Bibliographic Details
Published in:Carbohydrate research 2005-05, Vol.340 (7), p.1373-1377
Main Authors: Madhusudan, Soni Kamlesh, Agnihotri, Geetanjali, Negi, Devendra S., Misra, Anup Kumar
Format: Article
Language:English
Subjects:
Acetylation
Alkylation
Carbohydrates
Carbohydrates - chemistry
Heterogeneous reaction conditions
One-pot
Sodium hydroxide
Sodium Hydroxide - chemistry
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Summary:[Display omitted] A convenient one-pot protocol for the direct conversion of acyl-protected carbohydrates into their alkylated counterparts has been developed by using alkyl halides in the presence of solid sodium hydroxide and a phase transfer catalyst. These economically convenient, mild, two-phase reaction conditions allow the preparation of a variety of monosaccharide intermediates for use in the synthesis of complex oligosaccharides.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2005.03.007