Biopreservation of Red Blood Cells: Past, Present, and Future

Preservation and long-term storage of red blood cells (RBCs) is needed to ensure a readily available, safe blood supply for transfusion medicine. Effective preservation procedures are required at various steps in the production of a RBC product including testing, inventory, quality control, and prod...

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Bibliographic Details
Published in:Transfusion medicine reviews 2005-04, Vol.19 (2), p.127-142
Main Authors: Scott, Kirby L., Lecak, Jelena, Acker, Jason P.
Format: Article
Language:English
Subjects:
Blood Component Transfusion - methods
Blood Preservation - methods
Blood Preservation - trends
Cold Temperature
Cryopreservation - methods
Cryoprotective Agents - administration & dosage
Cryoprotective Agents - metabolism
Erythrocyte Transfusion - methods
Erythrocytes - cytology
Erythrocytes - drug effects
Erythrocytes - physiology
Freeze Drying
Glycerol - chemistry
Humans
Models, Biological
Preservation, Biological - methods
Preservation, Biological - trends
Specimen Handling
Temperature
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Summary:Preservation and long-term storage of red blood cells (RBCs) is needed to ensure a readily available, safe blood supply for transfusion medicine. Effective preservation procedures are required at various steps in the production of a RBC product including testing, inventory, quality control, and product distribution. Biopreservation is the process of maintaining the integrity and functionality of cells held outside the native environment for extended storage times. The biopreservation of RBCs for clinical use can be categorized based on the techniques used to achieve biologic stability and ensure a viable state after long-term storage. This paper will review the history, science, current practices, and emerging technologies of current RBC biopreservation approaches: hypothermic storage, cryopreservation, and lyophilization.
ISSN:0887-7963
1532-9496
DOI:10.1016/j.tmrv.2004.11.004