Lobar holoprosencephaly: prenatal MR diagnosis with postnatal MR correlation

Holoprosencephaly is a congenital anomaly characterized by lack of cleavage of the prosencephalon. Although, relatively rare, it is the most common anomaly that involves both the brain and the face. Prenatal diagnosis of this anomaly using ultrasonography, particularly of the less severe forms, is d...

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Bibliographic Details
Published in:Prenatal diagnosis 2005-04, Vol.25 (4), p.296-299
Main Authors: Wong, Alex M.-C., Bilaniuk, Larissa T., Ng, K.-K., Chang, Y.-L., Chao, A.-S., Wai, Y.-Y.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Brain - abnormalities
Brain - pathology
Female
Follow-Up Studies
Gestational Age
Gynecology. Andrology. Obstetrics
Holoprosencephaly - diagnosis
Holoprosencephaly - pathology
Hormonal contraception
Humans
Infant, Newborn
lobar holoprosencephaly
Magnetic Resonance Imaging
Male
Malformations of the nervous system
Medical sciences
MRI
Neurology
Pregnancy
prenatal diagnosis
Prenatal Diagnosis - methods
Reproducibility of Results
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Summary:Holoprosencephaly is a congenital anomaly characterized by lack of cleavage of the prosencephalon. Although, relatively rare, it is the most common anomaly that involves both the brain and the face. Prenatal diagnosis of this anomaly using ultrasonography, particularly of the less severe forms, is difficult. Magnetic resonance imaging has recently become an important complement to US in prenatal diagnosis of CNS anomalies. We herein report a patient in whom, at 23 weeks of gestation, US suggested agenesis of the corpus callosum and in whom, at 24 weeks of gestation, MRI correctly diagnosed lobar holoprosencephaly, which was confirmed by a postnatal MRI at 3 weeks of age. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.1108