Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM

Adrenomedullin (AM), an ubiquitous regulatory peptide with different actions, is known to be elevated in different clinical situations, including diabetes mellitus (DM), but its potential role in the pathogenesis of diabetic vascular complications is not clear. In the present study, we examined plas...

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes and its complications 2005-05, Vol.19 (3), p.147-154
Main Authors: García-Unzueta, M T, Berrazueta, J R, Pesquera, C, Obaya, S, Fernández, M D, Sedano, C, Amado, J A
Format: Article
Language:English
Subjects:
Acids
Adrenomedullin
Adult
Biomarkers - blood
Blood pressure
Cytokines
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - physiopathology
Diabetic Angiopathies - epidemiology
Diabetic retinopathy
Diabetic Retinopathy - blood
Female
Gene expression
Heart attacks
Heart failure
Homocysteine
Humans
Inflammation - blood
Liver cirrhosis
Male
Middle Aged
Mortality
Peptides
Peptides - blood
Plasma
Proteins
Reference Values
Risk Factors
Sepsis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adrenomedullin (AM), an ubiquitous regulatory peptide with different actions, is known to be elevated in different clinical situations, including diabetes mellitus (DM), but its potential role in the pathogenesis of diabetic vascular complications is not clear. In the present study, we examined plasma total AM levels, and their association with different markers of endothelial dysfunction and with other established risk factors for cardiovascular diseases, in patients with Type 1 DM. We studied a total of 155 patients, 117 patients without any kind of vascular complications, 24 patients with retinopathy only, and 14 patients with retinopathy and microalbuminuria but normal renal function. None of them had clinical evidence of atherosclerotic disease. Compared with the control group (64 healthy participants), patients had raised fibrinogen, soluble E-selectin ((s)E-selectin), vascular cellular adhesion molecule (VCAM), angiotensin converting enzyme (ACE), and von Willebrand factor (vWf) (P
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2004.08.002