Analysis of the first night effect and sleep parameters in medically refractory epilepsy patients

To assess the first night effect (FNE) and compare sleep stage proportions to normative values in a sample of medically refractory epilepsy patients. Sleep parameters of 53 epilepsy patients, ages (18–56, mean: 34±12, 25 females 28 men), who underwent two consecutive nights of polysomnography (PSG)...

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Bibliographic Details
Published in:Sleep medicine 2005-05, Vol.6 (3), p.277-280
Main Authors: Marzec, Mary L., Selwa, Linda M., Malow, Beth A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants - therapeutic use
Electrocardiography
Electroencephalogram
Electroencephalography
Electromyography
Electrooculography
Epilepsy
Epilepsy - drug therapy
Epilepsy - physiopathology
Female
First night effect
Humans
Male
Middle Aged
Polysomnogram
Polysomnography
Sleep
Sleep - physiology
Sleep, REM - physiology
Slow wave sleep
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Summary:To assess the first night effect (FNE) and compare sleep stage proportions to normative values in a sample of medically refractory epilepsy patients. Sleep parameters of 53 epilepsy patients, ages (18–56, mean: 34±12, 25 females 28 men), who underwent two consecutive nights of polysomnography (PSG) were compared. Non-rapid eye movement (NREM) stage 3 and NREM stage 4 were combined as slow wave sleep (SWS). Sleep efficiency, sleep latency, rapid eye movement (REM) latency, number of stage shifts, total minutes and proportion of total sleep time for stage 1, stage 2, SWS, and REM sleep were compared between the 2 nights. SWS was the only parameter that differed between nights 1 and 2 for both total minutes ( P=0.02) and proportion of total sleep time ( P=0.01), although the means for both nights were within the normative range. Comparing sleep proportions to normative values indicates that our patients had increased NREM stage 1 and decreased REM sleep. We observed a minimal FNE in this sample of epilepsy patients manifested by reduced SWS. Multiple PSGs to accommodate the FNE may not be necessary in this population.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2005.01.002