The role of p53 in hypoxia-induced apoptosis

Hypoxia represents one of the most physiologically relevant stresses, having significant roles in both normal development and malignant progression. Exposure to severe hypoxia leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the response to DNA-damaging agen...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-06, Vol.331 (3), p.718-725
Main Authors: Hammond, Ester M., Giaccia, Amato J.
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Apoptosis - physiology
Cell Hypoxia - physiology
Cell Line, Tumor
DNA Damage
DNA-Binding Proteins - physiology
Gene Expression Regulation
Humans
Hypoxia - physiopathology
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Mice
Neoplasms - blood supply
Nuclear Proteins - physiology
Phosphorylation
Repressor Proteins - physiology
Transcription Factors - physiology
Transcriptional Activation
Tumor Suppressor Protein p53 - physiology
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Summary:Hypoxia represents one of the most physiologically relevant stresses, having significant roles in both normal development and malignant progression. Exposure to severe hypoxia leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the response to DNA-damaging agents, hypoxia-induced p53 has little or no transcriptional transactivation capabilities and instead seems to function primarily as a transrepressor in order to induce apoptosis.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.03.154