Partial sleep deprivation compromises gastric mucosal integrity in rats

The gastric mucosa is most susceptible to stress that has been shown to induce mucosal damage in humans and animals. This study aims to explore the underlying mechanisms of partial sleep deprivation, as a source of psychophysiological stress, on gastric functions and its effect on mucosal integrity....

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Bibliographic Details
Published in:Life sciences (1973) 2005-05, Vol.77 (2), p.220-229
Main Authors: Guo, Jin Sheng, Chau, Jenny Fung Ling, Cho, Chi Hin, Koo, Marcel Wing Leung
Format: Article
Language:English
Subjects:
Animals
Gastric acidity
Gastric Acidity Determination
Gastric Mucosa - blood supply
Gastric Mucosa - pathology
Gastric mucosal damage
Gastrin
Gastrins - blood
Histamine
Male
Noradrenaline
Norepinephrine - blood
Partial sleep deprivation
Rats
Rats, Sprague-Dawley
Sleep Deprivation - complications
Somatostatin
Stomach Ulcer - etiology
Stress, Psychological - complications
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Summary:The gastric mucosa is most susceptible to stress that has been shown to induce mucosal damage in humans and animals. This study aims to explore the underlying mechanisms of partial sleep deprivation, as a source of psychophysiological stress, on gastric functions and its effect on mucosal integrity. Sprague-Dawley rats were partially sleep deprived (PSD) for 7 or 14 days by housing inside slowly rotating drums. Gastric tissues and plasma were sampled at the end of the sleep deprivation periods and mucosal lesion scores were evaluated. Morphological examination was performed after Hematoxylin and Eosin staining. Plasma levels of noradrenaline, adrenaline, gastrin, histamine and somatostatin were determined with enzyme immunoassays. Gastric acidity was measured with acid-base titration in pylorus ligated rats. Gastric mucosal blood flow was evaluated with Laser Doppler Flowmetry. It was found that gastric lesions were induced in about 30%–50% of the PSD rats. Gastric acidity as well as plasma levels of noradrenaline, gastrin and histamine were elevated. Gastric mucosal blood flow and plasma somatostatin level were on the contrary reduced, especially in rats with PSD for 14 days. It is concluded that partial sleep deprivation compromises gastric mucosal integrity by increasing gastric acidity, plasma levels of noradrenaline, gastrin, histamine, and decreasing gastric mucosal blood flow. These results provided experimental evidence on the gastric damaging effects of PSD and it could be one of the risk factors contributing to gastric ulcer formation.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2004.12.027