A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men

The aim of the present study was to determine whether a single session of resistance exercise improves whole-body insulin sensitivity in healthy men for up to 24 h. Twelve male subjects (23 +/- 1 years) were studied over a period of 4 days during which they consumed a standardized diet, providing 0....

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Bibliographic Details
Published in:European journal of applied physiology 2005-05, Vol.94 (1-2), p.180-187
Main Authors: Koopman, René, Manders, Ralph J F, Zorenc, Antoine H G, Hul, Gabby B J, Kuipers, Harm, Keizer, Hans A, van Loon, Luc J C
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Adult
Blood Glucose - analysis
Exercise - physiology
Glucose Clamp Technique
Humans
Injections, Intravenous
Insulin
Insulin - administration & dosage
Insulin Resistance - physiology
Male
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Physical Endurance - physiology
Physical Exertion - physiology
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Summary:The aim of the present study was to determine whether a single session of resistance exercise improves whole-body insulin sensitivity in healthy men for up to 24 h. Twelve male subjects (23 +/- 1 years) were studied over a period of 4 days during which they consumed a standardized diet, providing 0.16 +/- 0.01 MJ.kg(-1).day(-1) containing 15 +/- 0.1 energy% (En%) protein, 29 +/ -0.1 En% fat and 55 +/- 0.3 En% carbohydrate. Insulin sensitivity was determined 24 h before and 24 h after a single resistance exercise session (8 sets of 10 repetitions at 75% of 1 repetition maximum for two leg exercise tasks) using an intravenous insulin tolerance test. Insulin sensitivity index was calculated by the decline in arterial blood glucose concentration following intravenous administration of a single bolus of human insulin (0.075 IU.kg(-1) fat free mass). Basal glucose and insulin concentrations were not changed up to 24 h after the resistance exercise. However, a substantial 13+/-5% improvement in whole-body insulin sensitivity was observed, 24 h after the resistance exercise (P < 0.05). This study shows that even a single session of resistance exercise improves whole-body insulin sensitivity for up to 24 h in healthy men, which is consistent with earlier observations following endurance exercise tasks.
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-004-1307-y