Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat

Community-acquired meticillin-resistant Staphylococcus aureus (MRSA) is becoming an important public-health problem. New strains of S aureus displaying unique combinations of virulence factors and resistance traits have been associated with high morbidity and mortality in the community. Outbreaks of...

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Bibliographic Details
Published in:The Lancet infectious diseases 2005-05, Vol.5 (5), p.275-286
Main Authors: Zetola, Nicola, Francis, John S, Nuermberger, Eric L, Bishai, William R
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Biological and medical sciences
Child
Community-Acquired Infections - drug therapy
Community-Acquired Infections - epidemiology
Community-Acquired Infections - mortality
Furunculosis - microbiology
Furunculosis - physiopathology
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Methicillin Resistance - genetics
Microbial Sensitivity Tests
Pathogens
Pharmacology. Drug treatments
Prevalence
Public health
Staphylococcal Infections - drug therapy
Staphylococcal Infections - physiopathology
Staphylococcal Infections - transmission
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - pathogenicity
Virulence
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Summary:Community-acquired meticillin-resistant Staphylococcus aureus (MRSA) is becoming an important public-health problem. New strains of S aureus displaying unique combinations of virulence factors and resistance traits have been associated with high morbidity and mortality in the community. Outbreaks of epidemic furunculosis and cases of severe invasive pulmonary infections in young, otherwise healthy people have been particularly noteworthy. We review the characteristics of these new strains of community-acquired MRSA that have contributed to their pathogenicity and discuss new approaches to the diagnosis and management of suspected and confirmed community-acquired MRSA infections.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(05)70112-2