Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: Comparison with other steroid metabolizing enzymes

Effects of phytoestrogens on human health have been reported for decades. These include not only beneficial action in cancer prevention but also endocrine disruption in males. Since then many molecular mechanisms underlying these effects have been identified. Targets of phytoestrogens comprise stero...

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Bibliographic Details
Published in:Journal of steroid biochemistry and molecular biology 2005-02, Vol.93 (2), p.285-292
Main Authors: Deluca, D., Krazeisen, A., Breitling, R., Prehn, C., Möller, G., Adamski, J.
Format: Article
Language:English
Subjects:
17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors
17beta-Hydroxysteroid dehydrogenase
Biological and medical sciences
Diet
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacokinetics
Enzyme Inhibitors - pharmacology
Female
Flavonoids
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Male
Molecular Structure
Phytoestrogens
Phytoestrogens - chemistry
Phytoestrogens - pharmacokinetics
Phytoestrogens - pharmacology
Steroids - chemistry
Steroids - metabolism
Vertebrates: endocrinology
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Summary:Effects of phytoestrogens on human health have been reported for decades. These include not only beneficial action in cancer prevention but also endocrine disruption in males. Since then many molecular mechanisms underlying these effects have been identified. Targets of phytoestrogens comprise steroid receptors, steroid metabolising enzymes, elements of signal transduction and apoptosis pathways, and even the DNA processing machinery. Understanding the specific versus pleiotropic effects of selected phytoestrogens will be crucial for their biomedical application. This review will concentrate on the influence of phytoestrogens on 17beta-hydroxysteroid dehydrogenases from a comparative perspective with other steroid metabolizing enzymes.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2004.12.035