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Spontaneous " healing" of breast cancer
Healing is a phenomenon by which the intraductal component of breast cancer disappears and is replaced by fibrous tissue. Focally localized healing often prevents confirmation of the continuity of intraductal carcinoma. To clarify the clinicopathological characteristics of breast cancer with healing...
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| Published in: | Breast cancer (Tokyo, Japan) Japan), 2005, Vol.12 (2), p.140-144 |
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| Main Authors: | , , , , |
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| container_end_page | 144 |
| container_issue | 2 |
| container_start_page | 140 |
| container_title | Breast cancer (Tokyo, Japan) |
| container_volume | 12 |
| creator | Horii, Rie Akiyama, Futoshi Kasumi, Fujio Koike, Morio Sakamoto, Goi |
| description | Healing is a phenomenon by which the intraductal component of breast cancer disappears and is replaced by fibrous tissue. Focally localized healing often prevents confirmation of the continuity of intraductal carcinoma.
To clarify the clinicopathological characteristics of breast cancer with healing.
At our hospital, 308 patients (311 breasts) underwent breast conservation therapy without neoadjuvant chemotherapy for breast cancer in 2000. These surgical specimens were histopathologically investigated with 5 mm serial sections. We assessed the proportion and the characteristics of breast cancer with healing.
(1) The proportion of breast cancer with healing was 7% (21/311). (2) In the 21 patients, the mean age was 59.2 years, and the mean diameter was 2.8 cm. (3) The histological type of the breast cancer varied: noninvasive ductal carcinoma in 2 cases, papillotubular carcinoma in 5, solid-tubular carcinoma in 8, scirrhous carcinoma in 5, invasive lobular carcinoma in 1, and Paget's disease in 1. However in all cases, the histologic type of the intraductal carcinoma foci was the comedo/solid type and the nuclear grade of cancer cells was high. (4) In cases with healing, areas of healing were seen in an average of 5 (1-26) blocks, compared with intraductal carcinoma foci in 13 blocks (2-40). Healing was located on the nipple side of the main lesion in 8 cases, the peripheral side in 9, and both sides in 4. In 3 cases, healing was seen at the surgical margin of the partial mastectomy specimen.
The proportion of breast cancer cases with healing was 7% and these cases were intraductal carcinoma of the comedo/solid type, consisting of highly malignant cancer cells. |
| doi_str_mv | 10.2325/jbcs.12.140 |
| format | article |
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To clarify the clinicopathological characteristics of breast cancer with healing.
At our hospital, 308 patients (311 breasts) underwent breast conservation therapy without neoadjuvant chemotherapy for breast cancer in 2000. These surgical specimens were histopathologically investigated with 5 mm serial sections. We assessed the proportion and the characteristics of breast cancer with healing.
(1) The proportion of breast cancer with healing was 7% (21/311). (2) In the 21 patients, the mean age was 59.2 years, and the mean diameter was 2.8 cm. (3) The histological type of the breast cancer varied: noninvasive ductal carcinoma in 2 cases, papillotubular carcinoma in 5, solid-tubular carcinoma in 8, scirrhous carcinoma in 5, invasive lobular carcinoma in 1, and Paget's disease in 1. However in all cases, the histologic type of the intraductal carcinoma foci was the comedo/solid type and the nuclear grade of cancer cells was high. (4) In cases with healing, areas of healing were seen in an average of 5 (1-26) blocks, compared with intraductal carcinoma foci in 13 blocks (2-40). Healing was located on the nipple side of the main lesion in 8 cases, the peripheral side in 9, and both sides in 4. In 3 cases, healing was seen at the surgical margin of the partial mastectomy specimen.
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To clarify the clinicopathological characteristics of breast cancer with healing.
At our hospital, 308 patients (311 breasts) underwent breast conservation therapy without neoadjuvant chemotherapy for breast cancer in 2000. These surgical specimens were histopathologically investigated with 5 mm serial sections. We assessed the proportion and the characteristics of breast cancer with healing.
(1) The proportion of breast cancer with healing was 7% (21/311). (2) In the 21 patients, the mean age was 59.2 years, and the mean diameter was 2.8 cm. (3) The histological type of the breast cancer varied: noninvasive ductal carcinoma in 2 cases, papillotubular carcinoma in 5, solid-tubular carcinoma in 8, scirrhous carcinoma in 5, invasive lobular carcinoma in 1, and Paget's disease in 1. However in all cases, the histologic type of the intraductal carcinoma foci was the comedo/solid type and the nuclear grade of cancer cells was high. (4) In cases with healing, areas of healing were seen in an average of 5 (1-26) blocks, compared with intraductal carcinoma foci in 13 blocks (2-40). Healing was located on the nipple side of the main lesion in 8 cases, the peripheral side in 9, and both sides in 4. In 3 cases, healing was seen at the surgical margin of the partial mastectomy specimen.
The proportion of breast cancer cases with healing was 7% and these cases were intraductal carcinoma of the comedo/solid type, consisting of highly malignant cancer cells.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast - pathology</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - therapy</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Mastectomy, Segmental</subject><subject>Middle Aged</subject><subject>Neoplasm Regression, Spontaneous - pathology</subject><issn>1340-6868</issn><issn>1880-4233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpFkD1PwzAURS0EoqUwsaOoAwwoxc_vxXHGquJLqsQAzJbt2NAqTYqdDvx7UrUS073D0dXVYewa-EygKB7W1qUZiBkQP2FjUIrnJBBPh47Ec6mkGrGLlNacE5ZcnrMRFKpQRHLM7t63Xdub1ne7lE2zb2-aVfs1zbqQ2ehN6jNnWufjJTsLpkn-6pgT9vn0-LF4yZdvz6-L-TJ3WGGfB8PRQnA1cOuUcmRAKpBUCWsKb00gI7FGUYo6hGAJSClpECtJvBYEOGG3h91t7H52PvV6s0rON83hopZlWUEhigG8P4AudilFH_Q2rjYm_mrgeu9F771oEHrwMtA3x9md3fj6nz2KwD9ycVyA</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Horii, Rie</creator><creator>Akiyama, Futoshi</creator><creator>Kasumi, Fujio</creator><creator>Koike, Morio</creator><creator>Sakamoto, Goi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Spontaneous " healing" of breast cancer</title><author>Horii, Rie ; Akiyama, Futoshi ; Kasumi, Fujio ; Koike, Morio ; Sakamoto, Goi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-fa03b1fcd10bc88c4a16816492ba5ebaf4a63d3272dfffb414886a339640d2413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast - pathology</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - therapy</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Mastectomy, Segmental</topic><topic>Middle Aged</topic><topic>Neoplasm Regression, Spontaneous - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horii, Rie</creatorcontrib><creatorcontrib>Akiyama, Futoshi</creatorcontrib><creatorcontrib>Kasumi, Fujio</creatorcontrib><creatorcontrib>Koike, Morio</creatorcontrib><creatorcontrib>Sakamoto, Goi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horii, Rie</au><au>Akiyama, Futoshi</au><au>Kasumi, Fujio</au><au>Koike, Morio</au><au>Sakamoto, Goi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous " healing" of breast cancer</atitle><jtitle>Breast cancer (Tokyo, Japan)</jtitle><addtitle>Breast Cancer</addtitle><date>2005</date><risdate>2005</risdate><volume>12</volume><issue>2</issue><spage>140</spage><epage>144</epage><pages>140-144</pages><issn>1340-6868</issn><eissn>1880-4233</eissn><abstract>Healing is a phenomenon by which the intraductal component of breast cancer disappears and is replaced by fibrous tissue. Focally localized healing often prevents confirmation of the continuity of intraductal carcinoma.
To clarify the clinicopathological characteristics of breast cancer with healing.
At our hospital, 308 patients (311 breasts) underwent breast conservation therapy without neoadjuvant chemotherapy for breast cancer in 2000. These surgical specimens were histopathologically investigated with 5 mm serial sections. We assessed the proportion and the characteristics of breast cancer with healing.
(1) The proportion of breast cancer with healing was 7% (21/311). (2) In the 21 patients, the mean age was 59.2 years, and the mean diameter was 2.8 cm. (3) The histological type of the breast cancer varied: noninvasive ductal carcinoma in 2 cases, papillotubular carcinoma in 5, solid-tubular carcinoma in 8, scirrhous carcinoma in 5, invasive lobular carcinoma in 1, and Paget's disease in 1. However in all cases, the histologic type of the intraductal carcinoma foci was the comedo/solid type and the nuclear grade of cancer cells was high. (4) In cases with healing, areas of healing were seen in an average of 5 (1-26) blocks, compared with intraductal carcinoma foci in 13 blocks (2-40). Healing was located on the nipple side of the main lesion in 8 cases, the peripheral side in 9, and both sides in 4. In 3 cases, healing was seen at the surgical margin of the partial mastectomy specimen.
The proportion of breast cancer cases with healing was 7% and these cases were intraductal carcinoma of the comedo/solid type, consisting of highly malignant cancer cells.</abstract><cop>Japan</cop><pmid>15858446</pmid><doi>10.2325/jbcs.12.140</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1340-6868 |
| ispartof | Breast cancer (Tokyo, Japan), 2005, Vol.12 (2), p.140-144 |
| issn | 1340-6868 1880-4233 |
| language | eng |
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| source | Springer Nature |
| subjects | Aged Aged, 80 and over Breast - pathology Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma - pathology Carcinoma - therapy Female Fibrosis Humans Mastectomy, Segmental Middle Aged Neoplasm Regression, Spontaneous - pathology |
| title | Spontaneous " healing" of breast cancer |
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