Red Wine and Beer Elevate Blood Pressure in Normotensive Men

A positive relationship between alcohol consumption and blood pressure (BP) is well-established but the relative effect of specific alcoholic beverages is controversial. This study aimed to determine whether red wine may improve vascular function and have less of an impact on blood pressure because...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2005-05, Vol.45 (5), p.874-879
Main Authors: Zilkens, Renate R, Burke, Valerie, Hodgson, Jonathan M, Barden, Anne, Beilin, Lawrence J, Puddey, Ian B
Format: Article
Language:English
Subjects:
Adult
Beer
Blood Pressure - drug effects
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory
Brachial Artery - drug effects
Brachial Artery - physiology
Cross-Over Studies
Drinking - physiology
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Ethanol - pharmacology
Heart Rate - drug effects
Heart Rate - physiology
Humans
Male
Middle Aged
Nitroglycerin - pharmacology
Reference Values
Regional Blood Flow - drug effects
Sleep - physiology
Systole
Temperance
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - pharmacology
Wine
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Summary:A positive relationship between alcohol consumption and blood pressure (BP) is well-established but the relative effect of specific alcoholic beverages is controversial. This study aimed to determine whether red wine may improve vascular function and have less of an impact on blood pressure because of its high content of antioxidant vasodilator polyphenolic compounds. Healthy normotensive men entered a 4-period crossover study comparing in random order 4 weeks of control–abstinence with similar periods of daily consumption of red wine (375 mL; 39 grams alcohol), de-alcoholized red wine (375 mL), or beer (1125 mL; 41 grams alcohol). Ambulatory systolic BP and diastolic BP and heart rate (HR) were measured together with vascular function as assessed by flow-mediated dilatation (FMD) and glyceryl trinitrate-mediated (GTNMD) dilatation of the brachial artery. The systolic and diastolic BP and HR were not different between control–abstinence and de-alcoholized red wine. However, compared with control–abstinence, both red wine and beer increased awake systolic BP (2.9 and 1.9 mm Hg, respectively; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000164639.83623.76