Prevalence of aspirin resistance measured by PFA-100

Aspirin protects from cardiovascular events. However, a number of patients who take this drug suffer events, probably due to aspirin resistance. Our objective was to determine the prevalence of aspirin resistance in patients taking this drug and to test if resistance is related to different variable...

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Bibliographic Details
Published in:International journal of cardiology 2005-05, Vol.101 (1), p.71-76
Main Authors: Coma-Canella, Isabel, Velasco, Amelia, Castano, Sara
Format: Article
Language:English
Subjects:
Aged
Aspirin
Aspirin - pharmacology
Aspirin - therapeutic use
Biological and medical sciences
Brain Ischemia - prevention & control
Cardiology. Vascular system
Cross-Sectional Studies
Drug Resistance
Epinephrine closure time
Female
Humans
Male
Medical sciences
Middle Aged
Myocardial Ischemia - prevention & control
Platelet Aggregation Inhibitors - pharmacology
Platelet Aggregation Inhibitors - therapeutic use
Platelet function analyzer (PFA-100)
Platelet Function Tests
Prevalence
Time Factors
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Summary:Aspirin protects from cardiovascular events. However, a number of patients who take this drug suffer events, probably due to aspirin resistance. Our objective was to determine the prevalence of aspirin resistance in patients taking this drug and to test if resistance is related to different variables. Platelet function was studied in 113 patients (90 men) aged 63±9 (80 with stable ischaemic heart disease) who took aspirin (100 to 300 mg/day). By a platelet function analyzer, called PFA-100, the epinephrine closure time was studied. We also analysed the possible relationship between epinephrine closure time and the following variables: total cholesterol, LDL, HDL cholesterol, total/HDL cholesterol, triglycerides, lipoprotein(a), and C reactive protein. The possible association between aspirin resistance (epinephrine closure time
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2004.03.069