Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin-RNA Complex

In the groove: The crystal structure of the bacterial decoding‐site RNA in a complex with the antibiotic apramycin reveals how glycoside scaffolds participate in RNA recognition by natural products through the formation of pseudo base pairs and triples. The structure suggests that the inhibitory act...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-04, Vol.44 (18), p.2694-2700
Main Authors: Han, Qing, Zhao, Qiang, Fish, Sarah, Simonsen, Klaus B., Vourloumis, Dionisios, Froelich, Jamie M., Wall, Daniel, Hermann, Thomas
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
antibiotics
Base Pairing
Base Sequence
Crystallography, X-Ray
glycosides
Glycosides - chemistry
Glycosides - metabolism
Hydrogen Bonding
Models, Molecular
molecular recognition
Molecular Sequence Data
Nebramycin - analogs & derivatives
Nebramycin - chemistry
Nebramycin - metabolism
RNA
RNA - chemistry
RNA - metabolism
structure-activity relationships
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the groove: The crystal structure of the bacterial decoding‐site RNA in a complex with the antibiotic apramycin reveals how glycoside scaffolds participate in RNA recognition by natural products through the formation of pseudo base pairs and triples. The structure suggests that the inhibitory action of apramycin is based on interaction of the antibiotic with ribosomal protein S12 (see structural model), a control element of ribosome translocation.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200500028