Comparison of MRI and positron emission tomography for measuring myocardial perfusion reserve in healthy humans

Myocardial perfusion reserve (MPR, defined as the ratio of the maximum myocardial blood flow (MBF) to the baseline) is an indicator of coronary artery disease and myocardial microvascular abnormalities. First‐pass contrast‐enhanced magnetic resonance imaging (CE‐MRI) using gadolinium (Gd)‐DTPA as a...

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Published in:Magnetic resonance in medicine 2006-04, Vol.55 (4), p.772-779
Main Authors: Pärkkä, Jussi P., Niemi, Pekka, Saraste, Antti, Koskenvuo, Juha W., Komu, Markku, Oikonen, Vesa, Toikka, Jyri O., Kiviniemi, Tuomas O., Knuuti, Juhani, Sakuma, Hajime, Hartiala, Jaakko J.
Format: Article
Language:English
Subjects:
Adult
Blood Flow Velocity - physiology
Contrast Media - pharmacokinetics
contrast-enhanced MRI
Coronary Circulation - physiology
Dipyridamole - administration & dosage
Gadolinium DTPA - pharmacokinetics
Humans
Magnetic Resonance Imaging - methods
Male
myocardial blood flow
myocardial perfusion
positron emission tomography (PET)
Positron-Emission Tomography - methods
quantitative modeling
Vasodilator Agents - administration & dosage
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Summary:Myocardial perfusion reserve (MPR, defined as the ratio of the maximum myocardial blood flow (MBF) to the baseline) is an indicator of coronary artery disease and myocardial microvascular abnormalities. First‐pass contrast‐enhanced magnetic resonance imaging (CE‐MRI) using gadolinium (Gd)‐DTPA as a contrast agent (CA) has been used to assess MPR. Tracer kinetic models based on compartmental analysis of the CA uptake have been developed to provide quantitative measures of MBF by MRI. To study the accuracy of Gd‐DTPA first‐pass MRI and kinetic modeling for quantitative analysis of myocardial perfusion and MPR during dipyridamole infusion, we conducted a comparison with positron emission tomography (PET) in 18 healthy males (age = 40 ± 14 years). Five planes were acquired at every second heartbeat with a 1.5T scanner using a saturation recovery turboFLASH sequence. A perfusion‐related parameter, the unidirectional influx constant (Ki), was computed in three coronary artery territories. There was a significant correlation for both dipyridamole‐induced flow (0.70, P = 0.001) and MPR (0.48, P = 0.04) between MRI and PET. However, we noticed that MRI provided lower MPR values compared to PET (2.5 ± 1.0 vs. 4.3 ± 1.8). We conclude that MRI supplemented with tracer kinetic modeling can be used to quantify myocardial perfusion. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.20833