Negative inotropic action of propofol is enhanced in the acute ischemic myocardium of dogs

We investigated the effects of propofol on contractility and oxygen balance in acute ischemic myocardium and compared them with those of normal myocardium using a coronary microembolization model in dogs. In open-chest dogs, the left anterior descending coronary artery (LAD) was perfused through an...

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Bibliographic Details
Published in:Journal of anesthesia 2005-05, Vol.19 (2), p.136-141
Main Authors: Maekawa, Takuji, Cho, Sungsam, Takahashi, Shunji, Hara, Tetsuya, Tomiyasu, Shiro, Makita, Tetsuji, Sumikawa, Koji
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Care and treatment
Cerebrovascular Circulation - drug effects
Chloralose - pharmacology
Coronary heart disease
Depression, Chemical
Dogs
Health aspects
Myocardial Contraction - drug effects
Myocardial Infarction - physiopathology
Myocardial ischemia
Oxygen Consumption - drug effects
Propofol
Propofol - pharmacology
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Summary:We investigated the effects of propofol on contractility and oxygen balance in acute ischemic myocardium and compared them with those of normal myocardium using a coronary microembolization model in dogs. In open-chest dogs, the left anterior descending coronary artery (LAD) was perfused through an extracorporeal bypass from the carotid artery. Regional myocardial contractility and myocardial oxygen balance were evaluated along with segment shortening (%SS), regional myocardial oxygen consumption (MVO2), and lactate extraction ratio (LER) of the area perfused by the LAD. Acute ischemia was produced by repeated injection of microspheres into the LAD-perfused area until %SS decreased by 50% of baseline. In normal myocardium, intracoronary infusion of propofol at doses of 1.2 and 2.4 mg x kg(-1) x h(-1) caused slight decreases in %SS to 83% +/- 8% and 80% +/- 10%, respectively. In ischemic myocardium, propofol caused greater decreases in %SS (59% +/- 18% and 35% +/- 20%, respectively). The changes in MVO2 after propofol infusion generally paralleled the changes in %SS, but LER was not changed in either ischemic or normal myocardium. Propofol causes a greater decrease in the contractility of acute ischemic myocardium as compared with normal myocardium in which myocardial oxygen imbalance is not involved as a mechanism.
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-005-0304-6