Loading…

Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis

Non‐hormone‐secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S‐100 protein, cytokerat...

Full description

Saved in:
Bibliographic Details
Published in:Pathology international 2005-05, Vol.55 (5), p.244-247
Main Authors: Yamashita, Michiko, Qian, Zhi Rong, Sano, Toshiaki, Horvath, Eva, Kovacs, Kalman
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3
cites cdi_FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3
container_end_page 247
container_issue 5
container_start_page 244
container_title Pathology international
container_volume 55
creator Yamashita, Michiko
Qian, Zhi Rong
Sano, Toshiaki
Horvath, Eva
Kovacs, Kalman
description Non‐hormone‐secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S‐100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S‐100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type (‘CK‐type cell’) was cells weakly positive for S‐100 protein in the nucleus and for CK‐immunoreactivity in the cytoplasm. The next numerous type (‘S‐100 protein cell’) was cells strongly positive for S‐100 protein and weakly positive or negative for CK. The CK‐type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone ‐immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S‐100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so‐called stellate cells. GFAP‐positive cells were rare. It is implied that S‐100 protein‐positive FSC could be divided into at least two main subtypes: FC (CK‐type cells) and stellate cells (S‐100 protein cells).
doi_str_mv 10.1111/j.1440-1827.2005.01820.x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67800932</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67800932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3</originalsourceid><addsrcrecordid>eNqNUU1v1DAUtBAV_YC_gHzilvTZXsfJgQOq6LJStYAK4mg5_lCyOHGIE7H593XYVXvFF4_fmxk_jxHCBHKS1u0hJ5sNZKSkIqcAPIcEIT--QlfPjdcJMwoZ3xTsEl3HeAAgghXwBl0SXgoiKLlCw67r5j40bZyCbmzXauVxnGaz4NDjGLJ09tZgF7xv9ezViLX1PmLVvxRDnFJNTfbca3s8NRY3c6d6rIxN_ssQhmaJbXyLLpzy0b477zfo5_3nH3dfsoev293dp4dMc5pewGqqClOKWmx0xVWtSwaFqYFxy1zJjYHKuMpWBS-oE4YQClyV1hWOMuOoZjfow8l3GMOf2cZJdm1cx1O9DXOUhSgBKkYTsTwR9RhiHK2Tw9h2alwkAbmmLQ9yDVWuoco1bfkvbXlM0vfnO-a6s-ZFeI43ET6eCH9bb5f_NpbfdvsVJX120qfvscdnvRp_p_mZ4PLXfivF4_b-Eb7vJWFPeDifwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67800932</pqid></control><display><type>article</type><title>Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Yamashita, Michiko ; Qian, Zhi Rong ; Sano, Toshiaki ; Horvath, Eva ; Kovacs, Kalman</creator><creatorcontrib>Yamashita, Michiko ; Qian, Zhi Rong ; Sano, Toshiaki ; Horvath, Eva ; Kovacs, Kalman</creatorcontrib><description>Non‐hormone‐secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S‐100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S‐100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type (‘CK‐type cell’) was cells weakly positive for S‐100 protein in the nucleus and for CK‐immunoreactivity in the cytoplasm. The next numerous type (‘S‐100 protein cell’) was cells strongly positive for S‐100 protein and weakly positive or negative for CK. The CK‐type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone ‐immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S‐100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so‐called stellate cells. GFAP‐positive cells were rare. It is implied that S‐100 protein‐positive FSC could be divided into at least two main subtypes: FC (CK‐type cells) and stellate cells (S‐100 protein cells).</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/j.1440-1827.2005.01820.x</identifier><identifier>PMID: 15871721</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Adrenocorticotropic Hormone - analysis ; cytokeratin ; Female ; follicular cell ; folliculostellate cell ; Glial Fibrillary Acidic Protein - analysis ; Humans ; Immunohistochemistry ; Keratins - analysis ; Male ; Middle Aged ; pituitary ; Pituitary Gland, Anterior - chemistry ; Pituitary Gland, Anterior - pathology ; S-100 protein ; S100 Proteins - analysis</subject><ispartof>Pathology international, 2005-05, Vol.55 (5), p.244-247</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3</citedby><cites>FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15871721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamashita, Michiko</creatorcontrib><creatorcontrib>Qian, Zhi Rong</creatorcontrib><creatorcontrib>Sano, Toshiaki</creatorcontrib><creatorcontrib>Horvath, Eva</creatorcontrib><creatorcontrib>Kovacs, Kalman</creatorcontrib><title>Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>Non‐hormone‐secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S‐100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S‐100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type (‘CK‐type cell’) was cells weakly positive for S‐100 protein in the nucleus and for CK‐immunoreactivity in the cytoplasm. The next numerous type (‘S‐100 protein cell’) was cells strongly positive for S‐100 protein and weakly positive or negative for CK. The CK‐type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone ‐immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S‐100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so‐called stellate cells. GFAP‐positive cells were rare. It is implied that S‐100 protein‐positive FSC could be divided into at least two main subtypes: FC (CK‐type cells) and stellate cells (S‐100 protein cells).</description><subject>Adrenocorticotropic Hormone - analysis</subject><subject>cytokeratin</subject><subject>Female</subject><subject>follicular cell</subject><subject>folliculostellate cell</subject><subject>Glial Fibrillary Acidic Protein - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratins - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pituitary</subject><subject>Pituitary Gland, Anterior - chemistry</subject><subject>Pituitary Gland, Anterior - pathology</subject><subject>S-100 protein</subject><subject>S100 Proteins - analysis</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNUU1v1DAUtBAV_YC_gHzilvTZXsfJgQOq6LJStYAK4mg5_lCyOHGIE7H593XYVXvFF4_fmxk_jxHCBHKS1u0hJ5sNZKSkIqcAPIcEIT--QlfPjdcJMwoZ3xTsEl3HeAAgghXwBl0SXgoiKLlCw67r5j40bZyCbmzXauVxnGaz4NDjGLJ09tZgF7xv9ezViLX1PmLVvxRDnFJNTfbca3s8NRY3c6d6rIxN_ssQhmaJbXyLLpzy0b477zfo5_3nH3dfsoev293dp4dMc5pewGqqClOKWmx0xVWtSwaFqYFxy1zJjYHKuMpWBS-oE4YQClyV1hWOMuOoZjfow8l3GMOf2cZJdm1cx1O9DXOUhSgBKkYTsTwR9RhiHK2Tw9h2alwkAbmmLQ9yDVWuoco1bfkvbXlM0vfnO-a6s-ZFeI43ET6eCH9bb5f_NpbfdvsVJX120qfvscdnvRp_p_mZ4PLXfivF4_b-Eb7vJWFPeDifwQ</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Yamashita, Michiko</creator><creator>Qian, Zhi Rong</creator><creator>Sano, Toshiaki</creator><creator>Horvath, Eva</creator><creator>Kovacs, Kalman</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis</title><author>Yamashita, Michiko ; Qian, Zhi Rong ; Sano, Toshiaki ; Horvath, Eva ; Kovacs, Kalman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenocorticotropic Hormone - analysis</topic><topic>cytokeratin</topic><topic>Female</topic><topic>follicular cell</topic><topic>folliculostellate cell</topic><topic>Glial Fibrillary Acidic Protein - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratins - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pituitary</topic><topic>Pituitary Gland, Anterior - chemistry</topic><topic>Pituitary Gland, Anterior - pathology</topic><topic>S-100 protein</topic><topic>S100 Proteins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamashita, Michiko</creatorcontrib><creatorcontrib>Qian, Zhi Rong</creatorcontrib><creatorcontrib>Sano, Toshiaki</creatorcontrib><creatorcontrib>Horvath, Eva</creatorcontrib><creatorcontrib>Kovacs, Kalman</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamashita, Michiko</au><au>Qian, Zhi Rong</au><au>Sano, Toshiaki</au><au>Horvath, Eva</au><au>Kovacs, Kalman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2005-05</date><risdate>2005</risdate><volume>55</volume><issue>5</issue><spage>244</spage><epage>247</epage><pages>244-247</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Non‐hormone‐secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S‐100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S‐100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type (‘CK‐type cell’) was cells weakly positive for S‐100 protein in the nucleus and for CK‐immunoreactivity in the cytoplasm. The next numerous type (‘S‐100 protein cell’) was cells strongly positive for S‐100 protein and weakly positive or negative for CK. The CK‐type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone ‐immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S‐100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so‐called stellate cells. GFAP‐positive cells were rare. It is implied that S‐100 protein‐positive FSC could be divided into at least two main subtypes: FC (CK‐type cells) and stellate cells (S‐100 protein cells).</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15871721</pmid><doi>10.1111/j.1440-1827.2005.01820.x</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1320-5463
ispartof Pathology international, 2005-05, Vol.55 (5), p.244-247
issn 1320-5463
1440-1827
language eng
recordid cdi_proquest_miscellaneous_67800932
source Wiley-Blackwell Read & Publish Collection
subjects Adrenocorticotropic Hormone - analysis
cytokeratin
Female
follicular cell
folliculostellate cell
Glial Fibrillary Acidic Protein - analysis
Humans
Immunohistochemistry
Keratins - analysis
Male
Middle Aged
pituitary
Pituitary Gland, Anterior - chemistry
Pituitary Gland, Anterior - pathology
S-100 protein
S100 Proteins - analysis
title Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A15%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunohistochemical%20study%20on%20so-called%20follicular%20cells%20and%20folliculostellate%20cells%20in%20the%20human%20adenohypophysis&rft.jtitle=Pathology%20international&rft.au=Yamashita,%20Michiko&rft.date=2005-05&rft.volume=55&rft.issue=5&rft.spage=244&rft.epage=247&rft.pages=244-247&rft.issn=1320-5463&rft.eissn=1440-1827&rft_id=info:doi/10.1111/j.1440-1827.2005.01820.x&rft_dat=%3Cproquest_cross%3E67800932%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5240-3b2a6d87b74c95abc8306db035e3f85dd09df9e96562f7d11205a8ef6f23df2c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=67800932&rft_id=info:pmid/15871721&rfr_iscdi=true