Predicting clinical severity in sickle cell anaemia

Summary The ability to predict the phenotype of an individual with sickle cell anaemia would allow a reliable prognosis and could guide therapeutic decision making. Some risk factors for individual disease complications are known but are insufficiently precise to use for prognostic purposes; predict...

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Bibliographic Details
Published in:British journal of haematology 2005-05, Vol.129 (4), p.465-481
Main Author: Steinberg, M. H.
Format: Article
Language:English
Subjects:
alpha-Thalassemia - complications
alpha-Thalassemia - genetics
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - genetics
Anemia, Sickle Cell - pathology
Anemias. Hemoglobinopathies
Antisickling Agents - therapeutic use
Biological and medical sciences
Diseases of red blood cells
Female
fetal haemoglobin
Fetal Hemoglobin - analysis
genetic association
Genetic Predisposition to Disease
Globins - analysis
Hematologic and hematopoietic diseases
Hematology
Humans
Hydroxyurea - therapeutic use
Hypertension, Pulmonary - complications
Hypertension, Pulmonary - genetics
Linkage Disequilibrium
Male
Medical sciences
Phenotype
Polymorphism, Single Nucleotide
Priapism - complications
Priapism - genetics
Prognosis
sickle cell
Sickle cell anemia
single nucleotide polymorphisms
Stroke - complications
Stroke - genetics
Treatment Outcome
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Description
Summary:Summary The ability to predict the phenotype of an individual with sickle cell anaemia would allow a reliable prognosis and could guide therapeutic decision making. Some risk factors for individual disease complications are known but are insufficiently precise to use for prognostic purposes; predicting the global disease severity is not yet possible. Genetic association studies, which attempt to link gene polymorphisms with selected disease subphenotypes, may eventually provide useful methods of foretelling the likelihood of certain complications and allow better individualized treatment.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2005.05411.x