Concentrated hydroxyapatite inks for direct-write assembly of 3-D periodic scaffolds

Hydroxyapatite (HA) scaffolds with a 3-D periodic architecture and multiscale porosity have been fabricated by direct-write assembly. Concentrated HA inks with tailored viscoelastic properties were developed to enable the construction of complex 3-D architectures comprised of self-supporting cylindr...

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Bibliographic Details
Published in:Biomaterials 2005-10, Vol.26 (28), p.5632-5639
Main Authors: Michna, Sarah, Wu, Willie, Lewis, Jennifer A.
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Bone Substitutes - analysis
Bone Substitutes - chemistry
Bone tissue engineering
Cell Culture Techniques - methods
Crystallization - methods
Direct-write assembly
Elasticity
Extracellular Matrix - chemistry
Hydroxyapatite
Hydroxyapatites - chemistry
Ink
Materials Testing
Microfluidics - methods
Particle Size
Porosity
Scaffolds
Space life sciences
Specimen Handling - methods
Surface Properties
Tissue Engineering - methods
Viscosity
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Description
Summary:Hydroxyapatite (HA) scaffolds with a 3-D periodic architecture and multiscale porosity have been fabricated by direct-write assembly. Concentrated HA inks with tailored viscoelastic properties were developed to enable the construction of complex 3-D architectures comprised of self-supporting cylindrical rods in a layer-by-layer patterning sequence. By controlling their lattice constant and sintering conditions, 3-D periodic HA scaffolds were produced with a bimodal pore size distribution. Mercury intrusion porosimetry (MIP) was used to determine the characteristic pore size and volume associated with the interconnected pore channels between HA rods and the finer pores within the partially sintered HA rods.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2005.02.040