Sphenadilactones A and B, Two Novel Nortriterpenoids from Schisandra sphenanthera

Two novel nortriterpenoid compounds, sphenadilactones A (1) and B (2), have been isolated from the leaves and stems of Schisandra sphenanthera. The structural elucidation of 1 and 2 was accomplished by extensive NMR analysis. The relative stereochemistry of 1 was established by single-crystal X-ray...

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Bibliographic Details
Published in:Organic letters 2006-03, Vol.8 (7), p.1475-1478
Main Authors: Xiao, Wei-Lie, Pu, Jian-Xin, Chang, Ying, Li, Xiao-Li, Huang, Sheng-Xiong, Yang, Liu-Meng, Li, Li-Mei, Lu, Yang, Zheng, Yong-Tang, Li, Rong-Tao, Zheng, Qi-Tai, Sun, Han-Dong
Format: Article
Language:English
Subjects:
Anti-HIV Agents - chemistry
Anti-HIV Agents - isolation & purification
Anti-HIV Agents - pharmacology
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves - chemistry
Plant Stems - chemistry
Plants, Medicinal - chemistry
Schisandra - chemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Tumor Cells, Cultured
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Summary:Two novel nortriterpenoid compounds, sphenadilactones A (1) and B (2), have been isolated from the leaves and stems of Schisandra sphenanthera. The structural elucidation of 1 and 2 was accomplished by extensive NMR analysis. The relative stereochemistry of 1 was established by single-crystal X-ray crystallography. Both compounds were tested for their cytotoxicities against K562, A549, and HT-29, and compound 1 was further tested for its anti-HIV-1 activity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol060324d