Prodromal Angina Limits Infarct Size in the Setting of Acute Anterior Myocardial Infarction Treated With Primary Percutaneous Intervention

Because both groups showed myocardial reperfusion, as assessed by the concomitant presence of TIMI flow grade 3 and significant reduction of ΣST[arrow up], and no other major baseline clinical and angiographic differences were detected, our data suggest that infarct size reduction is mainly driven...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2005-05, Vol.45 (9), p.1545-1547
Main Authors: Ottani, Filippo, Galli, Mario, Zerboni, Santino, Galvani, Marcello
Format: Article
Language:English
Subjects:
Angina, Unstable - etiology
Angioplasty, Balloon, Coronary
Cardiology
Confidence intervals
Electrocardiography
Female
Heart attacks
Humans
Ischemia
Ischemic Preconditioning
Kinases
Male
Middle Aged
Myocardial Infarction - complications
Myocardial Infarction - pathology
Myocardial Infarction - therapy
Myocardial Reperfusion
Prospective Studies
Severity of Illness Index
Thrombolytic Therapy
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Summary:Because both groups showed myocardial reperfusion, as assessed by the concomitant presence of TIMI flow grade 3 and significant reduction of ΣST[arrow up], and no other major baseline clinical and angiographic differences were detected, our data suggest that infarct size reduction is mainly driven by preconditioning, when total occlusion time and reperfusion adequacy are controlled for. [...]in our study, prodromal angina leads to a smaller infarct size most likely through ischemic preconditioning.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2005.02.033