Complex between triple helix of collagen and double helix of DNA in aqueous solution

We demonstrate in this paper that one example of a biologically important and molecular self-assembling complex system is a collagen–DNA ordered aggregate which spontaneously forms in aqueous solutions. Interaction between the collagen and the DNA leads to destruction of the hydration shell of the t...

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Bibliographic Details
Published in:International journal of biological macromolecules 2005-06, Vol.35 (5), p.243-245
Main Authors: Mrevlishvili, George M., Svintradze, David V.
Format: Article
Language:English
Subjects:
Collagen
Collagen - chemistry
DNA
DNA - chemistry
DSC
Models, Molecular
Ordered complex
Protein Structure, Quaternary
Solutions
Thermodynamics
Water
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Summary:We demonstrate in this paper that one example of a biologically important and molecular self-assembling complex system is a collagen–DNA ordered aggregate which spontaneously forms in aqueous solutions. Interaction between the collagen and the DNA leads to destruction of the hydration shell of the triple helix and stabilization of the double helix structure. From a molecular biology point of view this nano-scale self-assembling superstructure could increase the stability of DNA against the nucleases during collagen diseases and the growth of collagen fibrills in the presence of DNA.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2005.02.004