Inhaled tobramycin in children with acute bacterial rhinopharyngitis

Antibiotic abuse for treating rhinopharyngitis induces the occurrence of resistant bacteria. As topical drugs might reduce this phenomenon, the aims of our study were to evaluate inhaled tobramycin in children with acute bacterial rhinopharyngitis and to compare it with oral amoxicillin/clavulanate....

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2006-01, Vol.19 (1), p.131-139
Main Authors: Varricchio, A, Tricarico, D, De Lucia, A, Utili, R, Tripodi, M-F, Miraglia Del Giudice, M, Capasso, M, Sabatino, G, Sgarrella, M, Marseglia, G L, Ciprandi, G
Format: Article
Language:English
Subjects:
Acute Disease
Adenoids - pathology
Administration, Inhalation
Airway Resistance
Amoxicillin-Potassium Clavulanate Combination - therapeutic use
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Bacteria
Child
Child, Preschool
Double-Blind Method
Female
Humans
Hypertrophy
Male
Manometry
Nasal Obstruction - drug therapy
Pharyngitis - drug therapy
Pharyngitis - microbiology
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Tobramycin - administration & dosage
Tobramycin - therapeutic use
Tympanic Membrane - pathology
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Summary:Antibiotic abuse for treating rhinopharyngitis induces the occurrence of resistant bacteria. As topical drugs might reduce this phenomenon, the aims of our study were to evaluate inhaled tobramycin in children with acute bacterial rhinopharyngitis and to compare it with oral amoxicillin/clavulanate. The trial was conducted as randomized, parallel group and double blind. Children, aged 3-6 years, with acute bacterial rhinopharyngitis were treated with 15 mg of aerosolized tobramycin (Group A) or 50 mg/Kg of amoxicillin/clavulanate (Group B) twice daily for 10 days. The following parameters were assessed: nasal obstruction, mucopurulent rhinorrhea, post-nasal drip, adenoidal hypertrophy, tympanic inflammation, tympanogram, rhinomanometry and cultures. Of 416 patients screened, 311 children (178 females and 133 males), median age 4.5 years, completed the study: 156 in Group A and 155 in Group B. Both treatments improved all parameters (p
ISSN:0394-6320
2058-7384
DOI:10.1177/205873920601900113