Childhood Levels of Immunoglobulins and Mannan‐Binding Lectin in Relation to Infections and Allergy

Respiratory tract infections, allergies and otitis media are common problems in early childhood. Our aim was to evaluate in a longitudinal community‐based cohort study the association between maturation of immunoglobulin (Ig) and mannan‐binding lectin (MBL) responses and disease manifestations in th...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2005-05, Vol.61 (5), p.466-474
Main Authors: Thórarinsdóttir, H. K., Lúdvíksson, B. R., Víkingsdóttir, T., Leópoldsdóttir, M. O., Árdal, B., Jónsson, T., Valdimarsson, H., Arason, G. J.
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Disease Susceptibility
Female
Humans
Hypersensitivity - blood
Hypersensitivity - immunology
Hypersensitivity - pathology
Immunoglobulin A - blood
Immunoglobulin G - blood
Immunoglobulin G - immunology
Infant
Male
Mannose-Binding Lectin - blood
Otitis Media - blood
Otitis Media - pathology
Recurrence
Respiratory Tract Infections - blood
Respiratory Tract Infections - pathology
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Summary:Respiratory tract infections, allergies and otitis media are common problems in early childhood. Our aim was to evaluate in a longitudinal community‐based cohort study the association between maturation of immunoglobulin (Ig) and mannan‐binding lectin (MBL) responses and disease manifestations in the first 4 years of life. Sustained low levels of IgA proved the strongest single indicator of susceptibility for recurrent otitis media (P = 0.008) and respiratory tract infections (P = 0.02), and this condition was also associated with low production of IgG subclasses. About 7% of the cohort had sustained low levels of MBL (
ISSN:0300-9475
1365-3083
DOI:10.1111/j.1365-3083.2005.01588.x