MRI findings in an atypical case of Kearns-Sayre syndrome: a case report

MR imaging features of mitochondrial encephalomyopathies, lactic acidosis, and stroke-like episodes, Kearns-Sayre/Pearson syndrome have been described in the literature. We describe extensive white matter changes with abnormal signal intensity lesions involving the deep gray nuclei and myelinated wh...

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Bibliographic Details
Published in:Neuroradiology 2005-04, Vol.47 (4), p.241-244
Main Authors: Sacher, Michael, Fatterpekar, Girish M, Edelstein, Simon, Sansaricq, Claude, Naidich, Thomas P
Format: Article
Language:English
Subjects:
Adolescent
Brain
Brain - pathology
Case studies
Diffusion Magnetic Resonance Imaging
Female
Humans
Kearns-Sayre Syndrome - pathology
Mitochondrial DNA
Neurological disorders
NMR
Nuclear magnetic resonance
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Summary:MR imaging features of mitochondrial encephalomyopathies, lactic acidosis, and stroke-like episodes, Kearns-Sayre/Pearson syndrome have been described in the literature. We describe extensive white matter changes with abnormal signal intensity lesions involving the deep gray nuclei and myelinated white matter tracts in an 18-year-old female with a large-scale 7.4 kb mitochondrial DNA deletion and a atypical presentation of Kearns-Sayre syndrome. Restricted diffusion due to status spongiosus at the involved sites is also discussed.
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-004-1314-z