Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls

This study examined whether abnormal responses to neurobiological challenge tests in borderline personality disorder (BPD) are related to a history of childhood sexual abuse (CSA). We compared patients meeting BPD criteria ( n = 24), with and without histories of CSA, with normal controls ( n = 12)...

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Bibliographic Details
Published in:Psychiatry research 2006-03, Vol.141 (3), p.337-341
Main Authors: Zweig-Frank, Hallie, Paris, Joel, Ng Ying Kin, N.M.K., Schwartz, George, Steiger, Howard, Vasavan Nair, N.P.
Format: Article
Language:English
Subjects:
Adolescent
Adrenergic alpha-Agonists - pharmacology
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Borderline Personality Disorder - diagnosis
Borderline Personality Disorder - epidemiology
Borderline Personality Disorder - psychology
Child
Child Abuse, Sexual - diagnosis
Child Abuse, Sexual - psychology
Child Abuse, Sexual - statistics & numerical data
Cholinesterase Inhibitors - pharmacology
Clonidine
Clonidine - pharmacology
Female
Humans
Medical sciences
Meta-chlorphenylpiperazine
Middle Aged
Personality disorders
Piperazines - pharmacology
Prolactin
Prolactin - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Pyridostigmine
Pyridostigmine Bromide - pharmacology
Serotonin
Serotonin Receptor Agonists - pharmacology
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - epidemiology
Stress Disorders, Post-Traumatic - psychology
Surveys and Questionnaires
Victimology
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Description
Summary:This study examined whether abnormal responses to neurobiological challenge tests in borderline personality disorder (BPD) are related to a history of childhood sexual abuse (CSA). We compared patients meeting BPD criteria ( n = 24), with and without histories of CSA, with normal controls ( n = 12) on the results of challenges with meta-chlorphenylpiperazine (m-CPP), pyridostigmine and clonidine. No differences were found between abused and non-abused patients with BPD. These results do not support the hypothesis that CSA is directly related to neurobiological abnormalities in BPD.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2005.02.009