Recent Developments in Mass Spectrometry for the Characterization of Nucleosides, Nucleotides, Oligonucleotides, and Nucleic Acids

Tremendous efforts have been made to develop and implement methodologies and mass spectrometric methods for the study of the monomeric constituents of nucleic acids. Banoub, et all put in perspective the progress in current biotechnological research in this area by highlighting the most popular ioni...

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Bibliographic Details
Published in:Chemical reviews 2005-05, Vol.105 (5), p.1869-1916
Main Authors: Banoub, Joseph H, Newton, Russell P, Esmans, Eddy, Ewing, David F, Mackenzie, Grahame
Format: Article
Language:English
Subjects:
Biotechnology
Cellular biology
Chemistry
Mass Spectrometry
Molecular Structure
Nucleic Acids - chemistry
Nucleosides - chemistry
Nucleotides - chemistry
Oligonucleotides - chemistry
Progress
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Summary:Tremendous efforts have been made to develop and implement methodologies and mass spectrometric methods for the study of the monomeric constituents of nucleic acids. Banoub, et all put in perspective the progress in current biotechnological research in this area by highlighting the most popular ionization methods, especially when used in conjunction with tandem mass spectrometry, and illustrating the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr030040w