The contributions of the right and left hemispheres of the brain to the polymorphism and heterogeneity of pyramidal syndrome

This study was conducted to address the clinical and neurophysiological features of pyramidal syndrome in patients with lateralized hemispheric lesions. A total of 52 patients were studied, all with hemiparesis following acute cerebrovascular accidents of the ischemic type in the right (24 patients)...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2005-03, Vol.35 (3), p.229-234
Main Authors: Ekusheva, E V, Vendrova, M I, Danilov, A B, Vein, A M
Format: Article
Language:English
Subjects:
Adult
Brain Ischemia - complications
Brain Ischemia - physiopathology
Female
Functional Laterality
Humans
Interneurons - pathology
Male
Middle Aged
Motor Skills
Paresis - etiology
Paresis - physiopathology
Pyramidal Cells - physiopathology
Pyramidal Tracts - blood supply
Pyramidal Tracts - physiopathology
Severity of Illness Index
Statistics, Nonparametric
Stroke - complications
Stroke - physiopathology
Synaptic Transmission
Syndrome
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Summary:This study was conducted to address the clinical and neurophysiological features of pyramidal syndrome in patients with lateralized hemispheric lesions. A total of 52 patients were studied, all with hemiparesis following acute cerebrovascular accidents of the ischemic type in the right (24 patients) or left (28 patients) hemispheres of the brain. Clinical neurological analysis was performed, along with transcranial magnetic stimulation, evoked abdominal reflexes, movement-associated motor potentials, and somatosensory evoked potentials. Lesions of the right hemisphere resulted in significant weakening of activatory influences at both the hemisphere level and on descending motor structures, with marked impairment of the afferent flow from both sides of the body and excessive disorganization of activity in the left, "presumptively healthy," side. Left-sided pathology impaired efferent control not only of the contralateral, but also of the ipsilateral side of the body. These data identify different neuroanatomical and neurophysiological features of the cerebral hemispheres not only in healthy people, but also in pathological conditions, this probably accounting for the polymorphism and heterogeneity of pyramidal syndrome in patients with lateralized cerebral lesions.
ISSN:0097-0549
1573-899X
DOI:10.1007/PL00022036