Lymphocyte subsets, TNFα and interleukin-4 levels in treated and untreated subacute sclerosing panencephalitis patients

Immunologic studies in relation to clinical status might help to understand the pathogenesis of subacute sclerosing panencephalitis (SSPE) and the effect of treatment. We measured lymphocyte subsets and intracellular TNFα and interleukin-4 levels in peripheral blood in SSPE patients. Patients had el...

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Bibliographic Details
Published in:Journal of neuroimmunology 2005-06, Vol.163 (1), p.195-198
Main Authors: Anlar, Banu, Guven, Alev, Köse, Gulsen, Okur, Hamza, Kose, Ozgü, Aydin, Omer F., Kabakus, Nimet, Altunbasak, Sakir, Herguner, Ozlem, Sonmez, Mujgan, Serdaroglu, Ayse
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Female
Flow cytometry
Humans
Immunity
Inosine Pranobex - therapeutic use
Interferons - therapeutic use
Interleukin-4 - blood
Lymphocyte
Lymphocyte Subsets - immunology
Lymphocyte Subsets - metabolism
Male
Subacute sclerosing panencephalitis
Subacute Sclerosing Panencephalitis - drug therapy
Subacute Sclerosing Panencephalitis - immunology
Tumor Necrosis Factor-alpha - metabolism
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Summary:Immunologic studies in relation to clinical status might help to understand the pathogenesis of subacute sclerosing panencephalitis (SSPE) and the effect of treatment. We measured lymphocyte subsets and intracellular TNFα and interleukin-4 levels in peripheral blood in SSPE patients. Patients had elevated percentages of CD8+ cells compared to age-matched control children. Rapidly progressive course was associated with increased CD4+ cells. Treatment with interferons and inosiplex altered the percentage of CD3+, CD4+ and CD19+ cells. TNFα and interleukin-4 levels had no correlation with course or treatment. The proportions of lymphocyte subsets appear to have a role in the evolution or manifestations of SSPE, if not in the pathogenesis.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2005.02.014