A case control study of glycoprotein status in ovarian carcinoma

Ovarian cancer is the leading cause of death due to gynecological malignancies. The aim of our study was to investigate the status of circulating glycoprotein levels in ovarian cancer patients. Thirty ovarian cancer patients and an equal number of age-matched, apparently healthy subjects as controls...

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Bibliographic Details
Published in:Clinical biochemistry 2005-06, Vol.38 (6), p.535-539
Main Authors: Aranganathan, Selvaraj, Senthil, Kumarasamy, Nalini, Namasivayam
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - blood
Case-Control Studies
Female
Fucose
Fucose - blood
Glycoproteins - blood
Hexosamine
Hexosamines - blood
Hexoses
Humans
Middle Aged
Neoplasm Staging
Ovarian cancer
Ovarian Neoplasms - blood
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - pathology
Prognosis
Sialic acid
Sialic Acids - blood
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Summary:Ovarian cancer is the leading cause of death due to gynecological malignancies. The aim of our study was to investigate the status of circulating glycoprotein levels in ovarian cancer patients. Thirty ovarian cancer patients and an equal number of age-matched, apparently healthy subjects as controls were involved in the study. Glycoprotein levels, as indicated by the concentration of plasma total sialic acid, protein-bound hexoses, hexosamine and fucose were estimated in circulation of both the ovarian cancer patients and controls. Significantly elevated levels of plasma total sialic acid, protein-bound hexoses, hexosamine and fucose were observed in ovarian cancer patients as compared to the apparently healthy controls. Plasma total sialic acid, protein-bound hexoses, hexosamine and fucose in the circulation of ovarian cancer patients are markedly elevated and the increase in these carbohydrate moieties of glycoproteins reflect the stage of cancer and may be an additional tool in the diagnosis and prognosis of ovarian carcinoma.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2005.01.004