Serum adenosine deaminase enzyme and plasma platelet factor 4 activities in active pulmonary tuberculosis, HIV-seropositive subjects and cancer patients

The aim of this study was to determine the serum adenosine deaminase (ADA) and plasma platelet factor (PF-4) activities in patients with active pulmonary tuberculosis, HIV seropositive subjects, cancer patients (acute and chronic type lymphoblastic leukaemia) and to compare them with the results of...

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Bibliographic Details
Published in:The Journal of infection 2006-04, Vol.52 (4), p.264-268
Main Authors: Tarhan, Gülnur, Gümüşlü, Feyzullah, Yilmaz, Neziha, Saka, Dilek, Ceyhan, İsmail, Cesur, Salih
Format: Article
Language:English
Subjects:
Adenosine deaminase
Adenosine Deaminase - blood
Adenosine Deaminase - metabolism
Adult
Bacterial diseases
Bacterial diseases of the respiratory system
Biological and medical sciences
Cancer
Case-Control Studies
Colorimetry
Female
General aspects
HIV
HIV Antibodies - blood
HIV Seropositivity - blood
HIV Seropositivity - enzymology
HIV Seropositivity - immunology
Human bacterial diseases
Human immunodeficiency virus
Human viral diseases
Humans
Immunoenzyme Techniques
Infectious diseases
Leukemia, Lymphoid - blood
Leukemia, Lymphoid - enzymology
Leukemia, Lymphoid - immunology
Male
Medical sciences
Mycobacterium
Mycobacterium tuberculosis - isolation & purification
Platelet Factor 4 - analysis
Platelet Factor 4 - metabolism
Platelet factor-4
Sputum - microbiology
Tuberculosis
Tuberculosis, Pulmonary - blood
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - enzymology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:The aim of this study was to determine the serum adenosine deaminase (ADA) and plasma platelet factor (PF-4) activities in patients with active pulmonary tuberculosis, HIV seropositive subjects, cancer patients (acute and chronic type lymphoblastic leukaemia) and to compare them with the results of healthy individuals. Eighty-eight subjects were enrolled in this study, 24 patients with active pulmonary tuberculosis, 20 patients with HIV seropositive subjects, 24 patients with cancer, 12 patients with acute type lymphoblastic leukaemia, 12 patients with chronic type lymphoblastic leukaemia) patients and 20 healthy individuals. ADA activity was determined in serum samples using colorimetric method and plasma PF4 activity was measured by using a sandwich-type enzyme immunoassay. When all study groups were compared with the control group, mean serum ADA activities were found to be significantly ( p
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2005.06.009