Combined reduced-antigen-content diphtheria–tetanus–acellular pertussis and polio vaccine (dTpa-IPV) for booster vaccination of adults

• Published in: Vaccine 2005-05, Vol.23 (28), p.3657-3667
• Main Authors: Grimprel, Emmanuel, von Sonnenburg, Frank, Sänger, Roland, Abitbol, Veronique, Wolter, Joanne M., Schuerman, Lode M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Adult; Age; Aged; Aging; Antibodies, Bacterial - blood; Antibodies, Viral - blood; Antigens; Applied microbiology; Bacterial diseases; Biological and medical sciences; Booster; Confidence intervals; Diphtheria; Diphtheria - prevention & control; Diphtheria Toxoid - administration & dosage; Diphtheria Toxoid - adverse effects; Diphtheria Toxoid - immunology; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology; Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage; Diphtheria-Tetanus-Pertussis Vaccine - adverse effects; Diphtheria-Tetanus-Pertussis Vaccine - immunology; dTpa-IPV; Ent and stomatologic bacterial diseases; Female; France; Fundamental and applied biological sciences. Psychology; Germany; Human bacterial diseases; Human viral diseases; Humans; Immunization, Secondary; Immunogenicity; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; Pertussis Vaccine - administration & dosage; Pertussis Vaccine - adverse effects; Pertussis Vaccine - immunology; Poliomyelitis - prevention & control; Poliovirus; Poliovirus Vaccine, Inactivated - administration & dosage; Poliovirus Vaccine, Inactivated - adverse effects; Poliovirus Vaccine, Inactivated - immunology; Prophylaxis; Public health; Tetanus; Tetanus - prevention & control; Tetanus Toxoid - administration & dosage; Tetanus Toxoid - adverse effects; Tetanus Toxoid - immunology; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Combined - administration & dosage; Vaccines, Combined - adverse effects; Vaccines, Combined - immunology; Viral diseases; Viral diseases of the nervous system; Whooping Cough - prevention & control
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2005.02.013

Many countries recommend diphtheria, tetanus and/or poliomyelitis boosters in adolescents or adults and the need for pertussis booster vaccination beyond childhood is increasingly recognized. A new combined reduced-antigen-content dTpa-IPV vaccine provides booster vaccination against all four diseases in one single injection. The immunogenicity and safety of the dTpa-IPV vaccine was compared to that of licensed dTpa + IPV or Td-IPV vaccines in 806 adolescents >14 years of age and adults with a heterogeneous vaccination history. The dTpa-IPV vaccine was immunogenic and well tolerated. No clinically significant differences were observed between groups. Anti-tetanus antibody kinetics indicated that each of the vaccines could be used for tetanus prophylaxis in acute wound management. For all vaccines, the lowest post-vaccination antibody concentrations were observed in subjects >40 years of age, those seronegative prior to vaccination and those subjects whose last vaccination was ≥20 years ago. In conclusion, dTpa-IPV vaccination of subjects over 14 years of age was as immunogenic and well tolerated as the licensed dTpa + IPV or Td-IPV vaccines. Vaccination coverage of adults is poor and the use of combined vaccines such as dTpa-IPV during vaccination visits, or for wound management, maximizes opportunities for boosting in these difficult to reach age groups.