First successful treatment of Nocardia farcinica brain abscess with moxifloxacin

Nocardia farcinica is an emerging pathogen in immunosuppressed patients causing both localized and disseminated infections. Many strains of this species are multidrug-resistant and require long-term antibiotic therapy, and consequently the choice of an oral treatment can be problematic. We report he...

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Bibliographic Details
Published in:The Journal of infection 2006-04, Vol.52 (4), p.e99-e102
Main Authors: Fihman, Vincent, Berçot, Béatrice, Mateo, Joaquim, Losser, Marie-Reine, Raskine, Laurent, Riahi, Jacques, Loirat, Philippe, Pors, Marie-José Sanson-Le
Format: Article
Language:English
Subjects:
16S rRNA gene
Anti-Infective Agents - therapeutic use
Aza Compounds - therapeutic use
Biopsy, Needle
Brain abscess
Brain Abscess - drug therapy
Fluoroquinolones
Humans
Immunocompromised Host
Immunosuppressive Agents - administration & dosage
Kidney Transplantation - immunology
Lung Abscess - pathology
Male
Microbial Sensitivity Tests
Middle Aged
Moxifloxacin
Nocardia - isolation & purification
Nocardia farcinica
Nocardia Infections - drug therapy
Organs transplant recipient
Quinolines - therapeutic use
RNA, Ribosomal, 16S - genetics
Tomography, X-Ray Computed
Treatment Outcome
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Summary:Nocardia farcinica is an emerging pathogen in immunosuppressed patients causing both localized and disseminated infections. Many strains of this species are multidrug-resistant and require long-term antibiotic therapy, and consequently the choice of an oral treatment can be problematic. We report here the first case of successful treatment of N. farcinica brain abscess in a renal transplant recipient with an extended-spectrum fluoroquinolone, moxifloxacin.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2005.08.001