Association between plasma activities of semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in patients with type 1 diabetes mellitus

Plasma semicarbazide-sensitive amine oxidase (SSAO) is elevated in patients with type 1 and type 2 diabetes and has been implicated in the pathophysiology of diabetic late complications. The regulation of SSAO production remains unknown. We studied correlations between plasma SSAO activity and param...

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Bibliographic Details
Published in:Diabetologia 2005-05, Vol.48 (5), p.1002-1007
Main Authors: BOOMSMA, F, PEDERSEN-BJERGAARD, U, AGERHOLM-LARSEN, B, HUT, H, DHAMRAIT, S. S, THORSTEINSSON, B, VAN DEN MEIRACKER, A. H
Format: Article
Language:English
Subjects:
Amine Oxidase (Copper-Containing) - blood
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
Body Mass Index
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - enzymology
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - blood
Diabetic Foot - blood
Diabetic Foot - surgery
Diabetic Nephropathies - blood
Diabetic Neuropathies - blood
Diabetic Retinopathy - blood
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzymes
Genotype & phenotype
Glycated Hemoglobin A - analysis
Humans
Hypertension
Internal medicine
Medical sciences
Pathophysiology
Peptidyl-Dipeptidase A - blood
Peptidyl-Dipeptidase A - genetics
Plasma
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Summary:Plasma semicarbazide-sensitive amine oxidase (SSAO) is elevated in patients with type 1 and type 2 diabetes and has been implicated in the pathophysiology of diabetic late complications. The regulation of SSAO production remains unknown. We studied correlations between plasma SSAO activity and parameters associated with diabetic late complications. Plasma SSAO was measured in a well-characterised group of 287 patients with type 1 diabetes. Standard statistical methods were used to investigate correlations with clinical parameters and components of the renin-angiotensin system. Overall, plasma SSAO was elevated, at 693+/-196 mU/l (mean+/-SD; normal controls 352+/-102 mU/l). Plasma SSAO was higher in the group with late complications or hypertension, and in patients treated with ACE-inhibitors. In univariate analysis a significant positive correlation (p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-005-1716-4