Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and Perspectives

L. Plum 1 ,2 ,3 , F. T. Wunderlich 1 ,3 , S. Baudler 1 ,3 , W. Krone 2 ,2 and J. C. Brüning 1 ,3 1 Department of Mouse Genetics and Metabolism, Institute for Genetics; 2 Department of Internal Medicine II; and 3 Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany Insulin r...

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Published in:Physiology (Bethesda, Md.) Md.), 2005-06, Vol.20 (3), p.152-161
Main Authors: Plum, L, Wunderlich, F. T, Baudler, S, Krone, W, Bruning, J. C
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - physiopathology
Disease Models, Animal
Insulin Resistance - physiology
Mice
Mice, Knockout
Mice, Transgenic
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Summary:L. Plum 1 ,2 ,3 , F. T. Wunderlich 1 ,3 , S. Baudler 1 ,3 , W. Krone 2 ,2 and J. C. Brüning 1 ,3 1 Department of Mouse Genetics and Metabolism, Institute for Genetics; 2 Department of Internal Medicine II; and 3 Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany Insulin resistance and type 2 diabetes are serious public health threats. Although enormous research efforts have been focused on the pathogenesis of these diseases, the underlying mechanisms remain only partly understood. Here we review mouse phenotypes resulting from inactivation of molecules responsible for the control of glucose metabolism that have led to novel insights into insulin action and the development of insulin resistance. In addition, more sophisticated strategies to manipulate genes in mice in the future are presented.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00049.2004