Effect of a Hydroxyapatite Tricalcium Phosphate Alloplast on Osseous Repair in the Rat Calvarium

Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to d...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2006-01, Vol.77 (1), p.39-45
Main Authors: Fleckenstein, Kurt B., Cuenin, Michael F., Peacock, Mark E., Billman, Michael A., Swiec, Gary D., Buxton, Thomas B., Singh, Baldev B., McPherson, James C.
Format: Article
Language:English
Subjects:
Animals
bone
Bone Diseases - pathology
Bone Diseases - surgery
Bone Substitutes - therapeutic use
Bone Transplantation - methods
Calcium Phosphates - therapeutic use
Dentistry
Disease Models, Animal
grafts
Hydroxyapatites - therapeutic use
Male
Membranes, Artificial
Microscopy, Electron, Scanning
Osteogenesis - physiology
Particle Size
Polytetrafluoroethylene
Porosity
Random Allocation
Rats
Rats, Sprague-Dawley
Reconstructive Surgical Procedures
Skull - pathology
Skull - surgery
wound healing
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Summary:Background: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA‐TCP) on osseous repair in the rat calvarium. Methods: Forty‐four adult male Harlan Sprague‐Dawley rats were assigned to one of four treatment groups: HA‐TCP macroporous disk, HA‐TCP microporous disk, HA‐TCP granules, and demineralized freeze‐dried bone (DFDB). The materials were placed into 8‐mm calvarial critical‐size defects (CSD). Calvariae were harvested at 10 weeks post‐surgery and evaluated histomorphometrically. Results: The DFDB group had significantly (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2006.77.1.39