Progressive knowledge loss: A longitudinal case study

The evolution of the progressive loss of semantic knowledge of a patient, VZ, with lesions mainly affecting the infero-medial temporal lobes, was followed for two years. At the beginning of the study VZ's performance was mainly characterized by a category-specific deficit for living things and...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2006-03, Vol.12 (2), p.275-284
Main Authors: MONDINI, SARA, BORGO, FRANCESCA, COTTICELLI, BIAGIO, BISIACCHI, PATRIZIA
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Anomia
Anomia - diagnosis
Anomia - physiopathology
Atrophy - pathology
Brain - pathology
Case reports
Cognition disorders
Cognition Disorders - diagnosis
Cognition Disorders - physiopathology
Deficits
Dementia
Disease Progression
Female
Humans
Longitudinal study
Magnetic Resonance Imaging
Middle Aged
NEUROBEHAVIORAL GRAND ROUNDS
Neuropsychological Tests
Patient
Patients
Semantic differential
Semantics
Theory
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Summary:The evolution of the progressive loss of semantic knowledge of a patient, VZ, with lesions mainly affecting the infero-medial temporal lobes, was followed for two years. At the beginning of the study VZ's performance was mainly characterized by a category-specific deficit for living things and a modality-specific deficit for perceptual attribute knowledge. As time went on, VZ's disorder affected all categories by changing the relationship between category and attribute knowledge. Data show that dissociations may change in the course of progressive cognitive breakdown, depending on both degeneration stage and task demands. VZ's performance is discussed in the light of the most influential theoretical accounts. Methodological suggestions regarding longitudinal studies of degenerative patients are also put forward. (JINS, 2006, 12, 275–284.)
ISSN:1355-6177
1469-7661
DOI:10.1017/S135561770606036X