Renal function during and after treatment for acute lymphoblastic leukemia in children

Renal function tests (cystatin C, serum and urine creatinine, creatinine clearance, serum and urine beta(2)-microglobulin, microalbuminuria, osmolality) were performed in 21 children at the diagnosis and during the treatment for acute lymphoblastic leukemia (ALL) (group I) and in 37 children (group...

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Published in:Pediatric nephrology (Berlin, West) West), 2005-06, Vol.20 (6), p.782-785
Main Authors: Krawczuk-Rybak, Maryna, Kuźmicz, Marta, Wysocka, Jolanta
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Blood pressure
Care and treatment
Case-Control Studies
Chemotherapy
Child
Creatinine
Creatinine - blood
Creatinine - urine
Cystatin C
Cystatins - blood
Humans
Kidney - physiopathology
Kidney diseases
Kidney Function Tests
Leukemia
Oncology
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology
Risk factors
Urine
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Summary:Renal function tests (cystatin C, serum and urine creatinine, creatinine clearance, serum and urine beta(2)-microglobulin, microalbuminuria, osmolality) were performed in 21 children at the diagnosis and during the treatment for acute lymphoblastic leukemia (ALL) (group I) and in 37 children (group II) treated for ALL 3.9+/-3.7 years before the study. The results were compared to 20 healthy children. Mean values of renal tests were in normal range at all points of analysis in groups I and II compared to the control group. Transitory higher cystatin C values (but in normal range) were observed after methotrexate administration and after the end of treatment. Deteriorated renal function was observed in one child during the treatment (after each protocol) and in five children treated previously for ALL. In conclusion, combined treatment for ALL is not associated with severe or long-term impairment of renal function.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-005-1839-3