No significant association of the 5′ end of neuregulin 1 and schizophrenia in a large Danish sample

• Published in: Schizophrenia research 2006-03, Vol.83 (1), p.1-5
• Main Authors: Ingason, Andrés, Søeby, Karen, Timm, Sally, Wang, August G., Jakobsen, Klaus D., Fink-Jensen, Anders, Hemmingsen, Ralf, Berg Rasmussen, Henrik, Werge, Thomas
• Format: Article
• Language: English
• Subjects: Adult and adolescent clinical studies; Biological and medical sciences; Case-Control Studies; Denmark; Ethnicity; European Continental Ancestry Group - genetics; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Glutamate; Haplotype; Haplotypes; Human; Humans; Medical sciences; Nerve Tissue Proteins - genetics; Neuregulin-1; Neurodevelopment; Plasticity; Polymorphism, Single Nucleotide; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - ethnology; Schizophrenia - genetics
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/j.schres.2005.12.850

Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5′ end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5′ end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.