Agouti-Related Proteins (AGRPs) and Agouti-Signaling Peptide (ASIP) in Fish and Chicken

: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one frag...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-04, Vol.1040 (1), p.363-367
Main Authors: KLOVINS, JANIS, SCHIÖTH, HELGI B.
Format: Article
Language:English
Subjects:
ACTH
Agouti Signaling Protein
Agouti-Related Protein
AGRP
Amino Acid Sequence
Animals
ASIP
Chickens
Chickens - genetics
Danio rerio
Databases, Genetic
Evolution
Fish
Fishes - genetics
Fragments
Freshwater
Fugu
Genes
Intercellular Signaling Peptides and Proteins - genetics
Molecular Sequence Data
Peptides
Phylogeny
Proteins - genetics
Sequences
Species Specificity
Takifugu rubripes
Tetraodon
Tetraodon nigroviridis
Vertebrates
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Summary:: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two from Fugu (Takifugu rubripes), and three from Tetraodon (Tetraodon nigroviridis). We have thus shown for the first time that both AGRP and ASIP genes exist in many species in “lower vertebrates” and were most probably present in early stages of vertebrate evolution.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1327.063