An experimental design for the development of adaptive treatment strategies

In adaptive treatment strategies, the treatment level and type is repeatedly adjusted according to ongoing individual response. Since past treatment may have delayed effects, the development of these treatment strategies is challenging. This paper advocates the use of sequential multiple assignment...

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Bibliographic Details
Published in:Statistics in medicine 2005-05, Vol.24 (10), p.1455-1481
Main Author: Murphy, S. A.
Format: Article
Language:English
Subjects:
Algorithms
Clinical Protocols
Clinical trials
dynamic treatment regimes
Humans
Medical treatment
Models, Statistical
multi-stage decision problems
Problem Solving
Randomized Controlled Trials as Topic
Research Design - statistics & numerical data
Sample Size
sequential multiple assignment randomized trial
Statistical analysis
therapeutic strategies
Therapeutics
treatment algorithms
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Summary:In adaptive treatment strategies, the treatment level and type is repeatedly adjusted according to ongoing individual response. Since past treatment may have delayed effects, the development of these treatment strategies is challenging. This paper advocates the use of sequential multiple assignment randomized trials in the development of adaptive treatment strategies. Both a simple ad hoc method for ascertaining sample sizes and simple analysis methods are provided. Copyright © 2004 John Wiley & Sons, Ltd.
ISSN:0277-6715
1097-0258
DOI:10.1002/sim.2022