Aponeocarzinostatin—A superior drug carrier exhibiting unusually high endurance against denaturants

Stability of apoNCS is discerned via its resistance against denaturants in comparison proteins known to be stable. Its unusual structural stability suggests its inherent superiority as a drug delivery system. The enediyne antitumor antibiotic chromoproteins are very potent in causing DNA damages. Du...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2006-05, Vol.14 (10), p.3543-3552
Main Authors: Sudhahar, Christopher G., Chin, Der-Hang
Format: Article
Language:English
Subjects:
Analysis
Antineoplastic agents
Antitumor antibiotic chromoprotein
Aponeocarzinostatin
Apoproteins - chemistry
Apoproteins - pharmacology
Biological and medical sciences
Circular Dichroism
Denaturants
Drug Carriers - chemistry
Drug Carriers - pharmacology
Enediyne
General aspects
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Organic Chemicals - chemistry
Pharmacology. Drug treatments
Protein Conformation - drug effects
Protein Denaturation
Zinostatin - chemistry
Zinostatin - pharmacology
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Summary:Stability of apoNCS is discerned via its resistance against denaturants in comparison proteins known to be stable. Its unusual structural stability suggests its inherent superiority as a drug delivery system. The enediyne antitumor antibiotic chromoproteins are very potent in causing DNA damages. During the drug delivery time course, the stability of the carrier protein becomes an important concern. To simulate conceivably offensive environment in biological contexts, such as cell membrane, we studied structural endurance of aponeocarzinostatin against several denaturants by circular dichroism and nuclear magnetic resonance spectroscopy. For comparison, we also examined proteins known to be stable and similar in size to aponeocarzinostatin. The results highlight the unusual structural stability of aponeocarzinostatin against chemical denaturants, suggesting the potential of aponeocarzinostatin as an inherently superior carrier in drug delivery systems.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2006.01.012