Trends in the evolution of the prodynorphin gene in teleosts: Cloning of eel and tilapia prodynorphin cDNAs

The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-fin...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-04, Vol.27 (4), p.797-804
Main Authors: Alrubaian, Jasem, Lecaude, Stephanie, Barba, Justin, Szynskie, Laura, Jacobs, Nicole, Bauer, David, Brown, Christopher, Kaminer, Irina, Bagrosky, Brian, Dores, Robert M.
Format: Article
Language:English
Subjects:
Actinopterygii
Amino Acid Sequence
Anguilla rostrata
Animals
Anura
Base Sequence
Biological and medical sciences
Cloning, Molecular
Danio rerio
DNA, Complementary - genetics
Dynorphin A
Dynorphin B
Eels - genetics
Enkephalins
Enkephalins - chemistry
Enkephalins - genetics
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Gnathostoma - metabolism
Humans
Molecular Sequence Data
Oreochromis niloticus
Phylogeny
Prodynorphin
Protein Precursors - chemistry
Protein Precursors - genetics
Sarcopterygii
Sequence Homology, Amino Acid
Teleost
Teleostei
Tilapia - genetics
Vertebrates: endocrinology
α-Neoendorphin
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Summary:The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloning of prodynorphin-related genes from the pufferfish and zebrafish supports the latter hypothesis. This study analyzes trends in the radiation of the prodynorphin gene in teleosts. Prodynorphin cDNAs were cloned from the brain of the eel Anguilla rostrata and the Nile tilapia, Oreochromis niloticus. These teleost prodynorphin sequences have distinct α-neoendorphin, dynorphin A, and dynorphin B sequences, and a novel opioid sequence, YGGFI. The relationship of these teleost prodynorphin sequences to other actinopterygian and sarcopterygian prodynorphin sequences will be discussed.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2005.09.007