Pleiotropic phenotype in Entamoeba histolytica overexpressing DNA methyltransferase (Ehmeth)

The protozoan parasite Entamoeba histolytica expresses a cytosine-5 DNA methyltransferase (Ehmeth) that belongs to the Dnmt2 proteins family. The biological function of members of the Dnmt2 family is unknown. Constitutive overexpression of Ehmeth resulted in a pleiotropic phenotype that includes acc...

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Bibliographic Details
Published in:Molecular and biochemical parasitology 2006-05, Vol.147 (1), p.48-54
Main Authors: Fisher, Ohad, Siman-Tov, Rama, Ankri, Serge
Format: Article
Language:English
Subjects:
5-Cytosine DNA methyltransferase
Amino Acid Sequence
Animals
DNA (Cytosine-5-)-Methyltransferases - chemistry
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA Methylation
DNA, Protozoan - metabolism
Entamoeba
Entamoeba histolytica
Entamoeba histolytica - genetics
Entamoeba histolytica - growth & development
Entamoeba histolytica - metabolism
Entamoeba histolytica - physiology
Gene Expression Regulation
Heat-Shock Response
HSP70
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Molecular Sequence Data
Multinucleated cells
Oxidative Stress
Phenotype
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Summary:The protozoan parasite Entamoeba histolytica expresses a cytosine-5 DNA methyltransferase (Ehmeth) that belongs to the Dnmt2 proteins family. The biological function of members of the Dnmt2 family is unknown. Constitutive overexpression of Ehmeth resulted in a pleiotropic phenotype that includes accumulation of multinucleated cells, upregulation of Heat shock protein 70 (HSP70) expression and resistance to oxidative stress. This pleiotropic phenotype suggests that Ehmeth plays an important role in the control of key cellular processes in the parasite.
ISSN:0166-6851
1872-9428
DOI:10.1016/j.molbiopara.2006.01.007