Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate‐specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging

OBJECTIVE To evaluate the reliability of prostate scintigraphy using a radiolabelled antibody (MUJ591) raised against the external domain of prostate‐specific membrane antigen (PSMA) in the staging of early prostate cancer. PATIENTS AND METHODS This was a prospective study of 16 patients who had rad...

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Bibliographic Details
Published in:BJU international 2005-06, Vol.95 (9), p.1232-1236
Main Authors: Nargund, Vinod, Al Hashmi, Dona, Kumar, Priya, Gordon, Stephen, Otitie, Ugo, Ellison, David, Carroll, Melvyn, Baithun, Sohail, Britton, Keith E.
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal - radiation effects
Antigens, Surface - immunology
Biological and medical sciences
Glutamate Carboxypeptidase II - immunology
histology
Humans
Iodine Radioisotopes
localized prostate cancer
Male
Medical sciences
Middle Aged
Neoplasm Staging - methods
Nephrology. Urinary tract diseases
Prostatic Neoplasms - diagnostic imaging
radiolabelled PSMA
Radionuclide Imaging
Radiopharmaceuticals
staging
Technetium
Tumors of the urinary system
Urinary tract. Prostate gland
Yttrium Radioisotopes
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Summary:OBJECTIVE To evaluate the reliability of prostate scintigraphy using a radiolabelled antibody (MUJ591) raised against the external domain of prostate‐specific membrane antigen (PSMA) in the staging of early prostate cancer. PATIENTS AND METHODS This was a prospective study of 16 patients who had radical retropubic prostatectomies (median PSA 9.75 ng/mL). All patients underwent PSMA imaging using MUJ591 radiolabelled with 99mTc using a photo‐reduction technique. RESULTS The findings of prostate imaging and histology were identical in seven patients. Scans showed understaging and overstaging in six and three patients, respectively. CONCLUSIONS PSMA scintigraphy using 99mTc‐labelled MUJ591 identifies the presence of prostate cancer, but is not sensitive in delineating micro‐invasion of the capsule, seminal vesicles or bladder neck. As in other studies it seems to be useful in detecting prostate bed recurrence and distant micrometastasis.
ISSN:1464-4096
1464-410X
DOI:10.1111/j.1464-410X.2005.05511.x